Successful vaccination of immune suppressed recipients using Listeria vector HIV-1 vaccines in helminth infected mice.
Successful vaccination of immune suppressed recipients using Listeria vector HIV-1 vaccines in helminth infected mice.
复制标题
使用李斯特菌载体 HIV-1 疫苗在感染蠕虫的小鼠中成功为免疫抑制的接受者接种疫苗。
DOI：
10.1016/j.vaccine.2013.02.037
复制
发表时间：
2013
期刊：
影响因子：
5.5
通讯作者：
Harn,Donald
中科院分区：
文献类型：
--
作者：
Shollenberger,LisaM;Bui,Cac;Paterson,Yvonne;Allen,Kelsey;Harn,Donald
艾滋病毒、疟疾和结核病疫苗仍然是高度优先事项，特别是对撒哈拉以南非洲人口而言。问题是：目前正在开发的针对这些疾病的疫苗是否能在蠕虫感染率高的人群中发挥作用？蠕虫寄生虫感染导致免疫抑制和免疫系统的CD4+ Th2偏斜，从而损害Th1型疫苗的效力。在这项研究中，我们在有和没有慢性蠕虫感染的小鼠中进行HIV疫苗试验，以模拟撒哈拉以南非洲和世界上其他蠕虫寄生虫流行地区的人类疫苗接受者人群，因为HIV和蠕虫感染的全球流行率存在很大的重叠。在这里，我们证明了单核细胞增生李斯特菌作为疫苗载体的功能，以驱动强大的和功能性的艾滋病毒特异性细胞免疫反应，无论慢性蠕虫感染。这一观察结果代表了疫苗研究领域的一个重大进展，并强调了开发中的疫苗应在目标人群中有效的概念。
Vaccines for HIV, malaria and TB remain high priorities, especially for sub-Saharan populations. The question is: will vaccines currently in development for these diseases function in populations that have a high prevalence of helminth infection? Infection with helminth parasites causes immune suppression and a CD4+ Th2 skewing of the immune system, thereby impairing Th1-type vaccine efficacy. In this study, we conduct HIV vaccine trials in mice with and without chronic helminth infection to mimic the human vaccine recipient populations in Sub-Saharan Africa and other helminth parasite endemic regions of the world, as there is large overlap in global prevalence for HIV and helminth infection. Here, we demonstrate that Listeria monocytogenes functions as a vaccine vector to drive robust and functional HIV-specific cellular immune responses, irrespective of chronic helminth infection. This observation represents a significant advance in the field of vaccine research and underscores the concept that vaccines in the developmental pipeline should be effective in the target populations.