Lithium dampens neurotransmitter response in smooth muscle: relevance to action in affective illness.
Lithium dampens neurotransmitter response in smooth muscle: relevance to action in affective illness.
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锂抑制平滑肌中的神经递质反应：与情感疾病的作用相关。
DOI：
10.1073/pnas.83.15.5727
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发表时间：
1986
影响因子：
11.1
通讯作者：
Snyder,SH
中科院分区：
文献类型：
--
作者：
Menkes,HA;Baraban,JM;Freed,AN;Snyder,SH
锂通过抑制磷酸肌醇代谢，干扰磷脂酰肌醇（“磷酸肌醇”）循环，其由许多激素和神经递质刺激。为了研究这种作用与神经传递的相关性，我们评估了锂处理对平滑肌对递质反应的影响。在锂预处理的气管肌肉中，卡巴胆碱或组胺收缩后的松弛被延迟。锂不影响由KCl和佛波醇12，13-二乙酸酯联合治疗引起的收缩后的舒张，这绕过了磷脂酰肌醇循环的受体刺激。锂的半数最大效应发生在1 mM，对应于治疗浓度。锂治疗对神经递质反应的抑制可能解释了锂缓解和预防躁狂症和抑郁症的独特能力。
Lithium, by inhibiting inositol phosphate metabolism, interferes with the phosphatidylinositol ("phosphoinositide") cycle, which is stimulated by numerous hormones and neurotransmitters. To examine the relevance of this action to neurotransmission, we evaluated effects of lithium treatment on smooth muscle responses to transmitters. In lithium-pretreated tracheal muscle, the relaxation following carbachol or histamine contractions is retarded. Lithium does not affect relaxation following contractions elicited by treatment with KCl and phorbol 12,13-diacetate in combination, which bypasses receptor stimulation of the phosphatidylinositol cycle. Half-maximal effects of lithium occur at 1 mM, corresponding to therapeutic concentrations. Dampening of neurotransmitter responses by lithium treatment may explain the unique ability of lithium to relieve and prevent both mania and depression.