How The Genome Got a Life Span.
How The Genome Got a Life Span.
复制标题
基因组如何获得寿命。
DOI：
10.1080/14636778.2015.1034851
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发表时间：
2015-04-03
影响因子：
1.8
通讯作者：
Landecker H
中科院分区：
文献类型：
--
作者：
Lappé M;Landecker H
在十年多一点的时间里，人类基因组的想法发生了重大变化，出现了基因组个体随着发育，年龄，疾病，环境输入和时间而变化的概念。本文探讨了基因组的出现与寿命，一个经历漂移，不稳定性和可变性，以及其他时间的变化主机。我们认为，染色质生物学的发展提供了经验和暴露的基因组体现的基础。我们通过染色质分析了时间对基因组的重要性，并分析了人类生命历程作为一组染色质物质变化的例子。具有寿命的基因组以新的方式将分子和经验结合起来，改变了生命阶段的观念，它们的相互关系，以及健康和疾病的暂时性。
In the space of little more than a decade, ideas of the human genome have shifted significantly, with the emergence of the notion that the genome an individual changes with development, age, disease, environmental inputs, and time. This paper examines the emergence of the genome with a life span, one that experiences drift, instability and mutability, and a host of other temporal changes. We argue that developments in chromatin biology have provided the basis for this genomic embodiment of experience and exposure. We analyze how time has come to matter for the genome through chromatin, providing analysis of examples in which the human life course is being explored as a set of material changes to chromatin. A genome with a lifespan aligns the molecular and the experiential in new ways, shifting ideas of life stages, their interrelation, and the temporality of health and disease.