The songbird syrinx morphome: a three-dimensional, high-resolution, interactive morphological map of the zebra finch vocal organ.
The songbird syrinx morphome: a three-dimensional, high-resolution, interactive morphological map of the zebra finch vocal organ.
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DOI：
10.1186/1741-7007-11-1
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发表时间：
2013-01-08
期刊：
影响因子：
5.4
通讯作者：
Elemans CP
中科院分区：
文献类型：
--
作者：
Düring DN;Ziegler A;Thompson CK;Ziegler A;Faber C;Müller J;Scharff C;Elemans CP
像人类婴儿一样，鸣禽通过模仿学习来学习物种特有的发音。鸟鸣系统已经成为一种广泛使用的实验动物模型，用于理解负责发声学习的潜在神经机制。然而，神经冲动是如何转化为复杂发声器官(空洞)的精确运动行为来创作歌曲的，人们还知之甚少。首先，我们对空洞的形态缺乏详细的了解。为了填补这一空白，我们结合了非侵入性(高场磁共振成像和微型计算机断层扫描)和侵入性技术(组织学和显微解剖)来构建带注释的斑雀(Taeniopygia Guttata)空洞的高分辨率三维数据集或形态组。我们以前所未有的细节在原位识别和注释了空洞软骨、骨和肌肉组织。我们提供了交互式三维模型，极大地改善了复杂形态数据的交流和我们对脊髓空洞功能的总体理解。我们的结果表明，在歌曲产生的生理限制的驱动下，针管骨架对于低重量是优化的。目前肌肉组织和特性的改进阐明了相对的肌肉是如何驱动不同的空洞症因素的。我们的数据集允许对肌肉共同激活和协同作用进行更准确的预测，并对肌肉活动和刺激实验具有重要意义。我们还演示了如何在歌唱过程中稳定脊髓空洞，以减少机械噪音，从而增强重复执行刻板印象的运动模式。此外，我们发现了一种软骨结构，适合在声音频率和幅度控制的解偶联中发挥关键作用，这使得对鸣禽进化成功的新解释成为可能。
Like human infants, songbirds learn their species-specific vocalizations through imitation learning. The birdsong system has emerged as a widely used experimental animal model for understanding the underlying neural mechanisms responsible for vocal production learning. However, how neural impulses are translated into the precise motor behavior of the complex vocal organ (syrinx) to create song is poorly understood. First and foremost, we lack a detailed understanding of syringeal morphology. To fill this gap we combined non-invasive (high-field magnetic resonance imaging and micro-computed tomography) and invasive techniques (histology and micro-dissection) to construct the annotated high-resolution three-dimensional dataset, or morphome, of the zebra finch (Taeniopygia guttata) syrinx. We identified and annotated syringeal cartilage, bone and musculature in situ in unprecedented detail. We provide interactive three-dimensional models that greatly improve the communication of complex morphological data and our understanding of syringeal function in general. Our results show that the syringeal skeleton is optimized for low weight driven by physiological constraints on song production. The present refinement of muscle organization and identity elucidates how apposed muscles actuate different syringeal elements. Our dataset allows for more precise predictions about muscle co-activation and synergies and has important implications for muscle activity and stimulation experiments. We also demonstrate how the syrinx can be stabilized during song to reduce mechanical noise and, as such, enhance repetitive execution of stereotypic motor patterns. In addition, we identify a cartilaginous structure suited to play a crucial role in the uncoupling of sound frequency and amplitude control, which permits a novel explanation of the evolutionary success of songbirds.
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影响因子：
5.3
作者：
d'Avella, Andrea;Portone, Alessandro;Lacquaniti, Francesco
通讯作者：
Lacquaniti, Francesco
DOI：
10.1523/jneurosci.6344-11.2012
发表时间：
2012-08-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chvatal SA;Ting LH
通讯作者：
Ting LH
DOI：
10.1073/pnas.0501846102
发表时间：
2005-05-03
影响因子：
11.1
作者：
Edwards, SV;Kingan, SB;Sorenson, MD
通讯作者：
Sorenson, MD
影响因子：
1.2
作者：
Elemans, CPH;Larsen, ON;Van Leeuwen, JL
通讯作者：
Van Leeuwen, JL
DOI：
10.1073/pnas.0500199102
发表时间：
2005-02-22
影响因子：
11.1
作者：
d'Avella, A;Bizzi, E
通讯作者：
Bizzi, E