Introduction of liquid-based cytology and human papillomavirus testing in cervical cancer screening in Luxembourg
Introduction of liquid-based cytology and human papillomavirus testing in cervical cancer screening in Luxembourg
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DOI：
10.1002/dc.23678
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发表时间：
2017-05-01
影响因子：
1.3
通讯作者：
Mossong, Joel
中科院分区：
文献类型：
--
作者：
Latsuzbaia, Ardashel;Hebette, Gaetan;Mossong, Joel
背景2014年，HPV分诊液基细胞学取代了传统细胞学。我们研究的目的是比较常规和液基细胞学（LBC），估计卢森堡筛查妇女中异常宫颈细胞学和高危HPV（hrHPV）感染的患病率及其相关性。815名妇女（平均年龄42.2岁）由国家细胞学实验室进行了调查。根据欧洲指南制备和筛选载玻片。所有的细胞学结果进行分类，根据Bethesda 2001系统的术语。结果异常宫颈病变的患病率如下：不典型鳞状细胞的意义不明（ASC-US），1.3%;低度鳞状上皮内病变（LSIL），1.9%;高度鳞状上皮内病变（HSIL），0.4%。LBC的细胞学病变检出率明显高于常规细胞学。基于11,838样本伴随细胞学和HPV检测，hrHPV检测9.5%，45.3%，70.0%，和92.6%的妇女细胞学阴性，ASC-US，LSIL，HSIL.ConclusionMore宫颈病变，确定使用LBC相比，传统的细胞学。HrHPV感染与上皮内病变的严重程度相关。目前的研究结果为评估卢森堡宫颈癌的预防和监测HPV疫苗接种的未来影响提供了重要信息。细胞病理学诊断。2017;45：384-390. (c)2017 Wiley Periodicals，Inc.
BackgroundIn 2014, liquid-based cytology with HPV triage replaced conventional cytology. The aim of our study was to compare conventional and liquid-based cytology (LBC), estimate the prevalence of abnormal cervical cytology and high risk HPV (hrHPV) infection and their correlation, among screened women in Luxembourg.MethodsBetween the first January 2013 and 31st December 2015, 315,868 cervical samples from 150,815 women (mean age 42.2years) were investigated by the national cytology laboratory. Slides were prepared and screened according to European Guidelines. All cytological results were classified according to the Bethesda 2001 system terminology.ResultsThe prevalence of abnormal cervical lesions was as follows: atypical squamous cells of undetermined significance (ASC-US), 1.3%; low-grade squamous intraepithelial lesion (LSIL), 1.9%; high-grade squamous intraepithelial lesion (HSIL), 0.4%. The detection rate of cytological lesions was significantly higher with LBC than with conventional cytology. Based on 11,838 samples with concomitant cytology and HPV testing, hrHPV was detected in 9.5, 45.3, 70.0, and 92.6% of women with negative cytology, ASC-US, LSIL, and HSIL, respectively.ConclusionMore cervical lesions were identified using LBC compared to conventional cytology. HrHPV infection was correlated with the severity of intraepithelial lesions. The current findings provide important information to evaluate the prevention of cervical cancer in Luxembourg and for monitoring the future impact of HPV vaccination. Diagn. Cytopathol. 2017;45:384-390. (c) 2017 Wiley Periodicals, Inc.