The superior temporal sulcus and the N170 during face processing: Single trial analysis of concurrent EEG-fMRI
The superior temporal sulcus and the N170 during face processing: Single trial analysis of concurrent EEG-fMRI
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DOI：
10.1016/j.neuroimage.2013.10.047
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发表时间：
2014-02-01
期刊：
影响因子：
5.7
通讯作者：
Cunnington, Ross
中科院分区：
文献类型：
--
作者：
Nguyen, Vinh T.;Cunnington, Ross
面部选择性神经信号已被可靠地识别使用EEG和fMRI研究。这些包括N170成分，在面部出现后约170 ms达到峰值的神经反应，以及梭状面区（FFA）、枕面部区（OFA）和上级颞沟（STS）的面部选择性激活。由于大多数神经影像学研究分别研究这些面孔选择性过程，N170神经反应和梭状回激活之间的关系仍然存在争议。在这项研究中，我们同时测量了EEG和fMRI反应直立的脸，倒置的脸，和对象来检查这种关联。我们介绍了一种方法，单次试验估计的N170振幅和相关性的试验的N170神经反应与功能磁共振BOLD反应的变化。对于直立脸，右侧STS的BOLD反应与N170振幅呈负相关，在N170振幅较大（更负）的试验中显示出更大的激活。对于倒置的脸，梭状回（mFG）的内侧区域与N170振幅呈正相关，在N170振幅较小（负性较小）的试验中显示出更大的激活。这一结果表明STS是产生与面部感知相关的N170的关键区域，并表明mFG被额外招募用于处理倒置面部，特别是在N170较小的试验中。尽管fMRI和EEG信号的时间分辨率不同，但我们的单次试验估计和EEG-fMRI相关方法可以揭示与面部感知相关的170 ms时面部选择性脑区激活和神经过程之间的关联。(C)2013 Elsevier Inc. All rights reserved.
Face-selective neural signals have been reliably identified using both EEG and fMRI studies. These consist of the N170 component, a neural response peaking approximately 170 ms after a face is presented, and face-selective activations in the fusiform face area (FFA), the occipital face area (OFA), and the superior temporal sulcus (STS). As most neuroimaging studies examine these face-selective processes separately, the relationship between the N170 neural response and activation in the fusiform gyrus is still debated. In this study, we concurrently measured EEG and fMRI responses to upright faces, inverted faces, and objects to examine this association. We introduce a method for single-trial estimation of N170 amplitudes and correlation of the trial-by-trial variation in N170 neural responses with fMRI BOLD responses. For upright faces, BOLD responses in the right STS were negatively correlated with N170 amplitudes, showing greater activation on trials in which N170 amplitudes were larger (more negative). For inverted faces, a medial region of the fusiform gyrus (mFG) was positively correlated with N170 amplitudes, showing greater activation on trials in which N170 amplitudes were smaller (less negative). This result points to the STS as a crucial region for generating the N170 associated with face perception, and suggests that the mFG is additionally recruited for processing inverted faces, particularly on trials in which N170 is small. Despite the different time resolution of fMRI and EEG signals, our single-trial estimation and EEG-fMRI correlation method can reveal associations between activation in face-selective brain regions and neural processes at 170 ms associated with face perception. (C) 2013 Elsevier Inc. All rights reserved.