Loss function of Bcr mutation causes gastrointestinal dysmotility and brain developmental defects
Loss function of Bcr mutation causes gastrointestinal dysmotility and brain developmental defects
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DOI：
10.1111/nmo.14190
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发表时间：
2021-06
影响因子：
3.5
通讯作者：
Yongtao Xiao;Yu-Fan Sun;Ying Lu;Jun Du;Xinbei Tian;W. Cai;Ying Wang
中科院分区：
文献类型：
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作者：
Yongtao Xiao;Yu-Fan Sun;Ying Lu;Jun Du;Xinbei Tian;W. Cai;Ying Wang
断点簇区（BCR）是一种最初与c-Abl酪氨酸激酶形成融合蛋白并诱导白血病的蛋白质。研究人员已经表明，BCR在中枢神经系统中富集，可能导致神经系统疾病。我们的目的是研究BCR在胃肠（GI）道和大脑神经发育中的生理功能。
The breakpoint cluster region (BCR) is a protein that originally forms a fusion protein with c‐Abl tyrosine kinase and induces leukemia. Researchers have shown that BCR is enriched in the central nervous system and may contribute to neurological disorders. We aimed to investigate the physiological function of BCR in neural development in the gastrointestinal (GI) tract and brain.