Perceiving patterns in random series: dynamic processing of sequence in prefrontal cortex
Perceiving patterns in random series: dynamic processing of sequence in prefrontal cortex
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DOI：
10.1038/nn841
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发表时间：
2002-05-01
影响因子：
25
通讯作者：
McCarthy, G
中科院分区：
文献类型：
--
作者：
Huettel, SA;Mack, PB;McCarthy, G
我们证明，在人类前额叶皮层的区域发展时刻到时刻的模式的事件发生在感觉环境中。受试者观看随机的二值序列图像，每张图像单独呈现，每张图像需要按下不同的按钮。图案是在呈现的一系列图像中偶然出现的。使用功能性磁共振成像（fMRI），我们确定了通过观看中断模式的刺激引起的活动。重复模式和交替模式均可诱发前额叶激活，且这种激活的幅度随模式长度的增加而增加。重复模式的违反，而不是交替模式的违反，激活了基底神经节。
We demonstrate that regions within human prefrontal cortex develop moment-to-moment models for patterns of events occurring in the sensory environment. Subjects viewed a random binary sequence of images, each presented singly and each requiring a different button press response. Patterns occurred by chance within the presented series of images. Using functional magnetic resonance imaging (fMRI), we identified activity evoked by viewing a stimulus that interrupted a pattern. Prefrontal activation was evoked by violations of both repeating and alternating patterns, and the amplitude of this activation increased with increasing pattern length. Violations of repeating patterns, but not of alternating patterns, activated the basal ganglia.