Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity.
Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity.
复制标题
[131I]MIBG 在携带 SK-N-SH 人神经母细胞瘤异种移植物的裸鼠中的定位：比活性的影响。
DOI：
10.1038/bjc.1996.226
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发表时间：
1996
影响因子：
8.8
通讯作者：
Zalutsky,MR
中科院分区：
文献类型：
--
作者：
Vaidyanathan,G;Friedman,HS;Keir,ST;Zalutsky,MR
The biodistribution of no-carrier-added (nca) meta-[131I] iodobenzylguanidine ([131I] MIBG) and that prepared by the standard isotopic exchange method were compared in athymic mice bearing SK-N-SH human neuroblastoma xenografts. No advantage in tumour uptake was observed for the nca preparation. BALB/c nu/nu mice exhibited lower uptake in highly innervated normal tissues (heart and adrenals) than normal BALB/c mice. In another experiment, the distribution of nca [131I] MIBG in the absence or presence (3-9 micrograms) of MIBG carrier was determined. At both 4 h and 24 h, the heart uptake was reduced by a factor of 1.5 even at a dose of 3 micrograms MIBG. Tumour uptake was not significantly altered by various amounts of unlabelled MIBG at either time point.
