Characteristic Epithelium with Low-Grade Atypia Appears on the Surface of Gastric Cancer after Successful Helicobacter pylori Eradication Therapy
Characteristic Epithelium with Low-Grade Atypia Appears on the Surface of Gastric Cancer after Successful Helicobacter pylori Eradication Therapy
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DOI：
10.1111/hel.12132
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发表时间：
2014-08-01
期刊：
影响因子：
4.4
通讯作者：
Chayama, Kazuaki
中科院分区：
文献类型：
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作者：
Kitamura, Yoko;Ito, Masanori;Chayama, Kazuaki
背景：成功根除幽门螺杆菌后胃癌的发病率一直在增加。我们曾报道过H.根除幽门方法：对27例胃癌患者行胃癌根治术后发现的ELA进行临床和生物学特性的研究。幽门螺杆菌根除治疗。我们研究了这些病例中ELA的患病率及其在H。根除幽门结果：27例ELA中有22例（81%）伴有与胃肿瘤相连续的低级别上皮样增生，与对照组比较差异有显著性（P < 0.01）。我们发现，胃型粘蛋白是经常表达在这上皮。无论p53或Ki67阳性细胞在ELA中均未发现，无论其在肿瘤组织中的表达如何。ELA的存在与H.结论：成功根除幽门螺杆菌治疗后，胃癌组织上常出现上皮细胞轻度增生，可能是由胃癌细胞发展而来。这种现象可能会影响胃癌内镜诊断的实践。
Background: The incidence of gastric cancer after successful Helicobacter pylori eradication has been increasing. We previously reported that epithelium with low-grade atypia (ELA) appeared on the surface of gastric cancer after H. pylori eradication. Here, we investigate the clinical and biological characteristics of such ELA.Methods: We studied 27 cases of gastric cancer detected after successful H. pylori eradication therapy. We examined the prevalence of ELA among these cases and its significance for endoscopic discovery after H. pylori eradication. We additionally investigated the mucus, p53 and Ki67 expressions in ELA.Results: Epithelium with low-grade atypia that continuous with the gastric tumor was detected in 22 of 27 cases (81%), a significantly greater percentage than that for controls (p < 0.01). We found that gastric-type mucin was frequently expressed in this epithelium. Neither p53-nor Ki67-positive cells were found in ELA, irrespective of their expression in tumor tissue. The presence of ELA was positively correlated with the clinical interval between H. pylori eradication and gastric cancer detection.Conclusions: Epithelium with low-grade atypia on gastric cancer tissue, which may develop from gastric cancer cells, is frequently present after successful eradication therapy. This phenomenon could influence the practice of endoscopic diagnosis of gastric cancers.