Maturation of Sensori-Motor Functional Responses in the Preterm Brain.
Maturation of Sensori-Motor Functional Responses in the Preterm Brain.
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DOI：
10.1093/cercor/bhv203
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发表时间：
2016-01
期刊：
影响因子：
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通讯作者：
Burdet E
中科院分区：
文献类型：
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作者：
Allievi AG;Arichi T;Tusor N;Kimpton J;Arulkumaran S;Counsell SJ;Edwards AD;Burdet E
早产会增加患脑瘫等疾病的风险，因此这段时间可能对大脑感觉运动系统的发育至关重要。然而，对于皮层感觉运动功能在这个时期是如何成熟的，发育是否受到经验的影响，以及它在自发运动行为中的作用，我们知之甚少。我们的目标是利用功能性MRI和定制的机器人刺激装置系统地表征这一时期感觉-运动功能脑活动的空间和时间成熟。我们研究了57名年龄在经后30 + 2至43 + 2周的婴儿。在诱导和自发的右手腕运动之后，我们在对侧（左）初级体感觉和运动皮层中看到了一致的正血氧水平依赖的功能反应。此外，我们看到了一个成熟的趋势，即更快，更高幅度，更分散的空间功能响应；同侧半球和感觉-运动联合区域的整合也在增加。我们还发现，大脑半球间功能连通性与子宫外暴露显著相关，表明经验依赖机制的影响。在学期等效年龄，我们发现反应幅度和半球间功能连通性都有所下降，而空间特异性有所增加，最终形成了与成人相似的感觉-运动功能反应。
Preterm birth engenders an increased risk of conditions like cerebral palsy and therefore this time may be crucial for the brain's developing sensori-motor system. However, little is known about how cortical sensori-motor function matures at this time, whether development is influenced by experience, and about its role in spontaneous motor behavior. We aimed to systematically characterize spatial and temporal maturation of sensori-motor functional brain activity across this period using functional MRI and a custom-made robotic stimulation device. We studied 57 infants aged from 30 + 2 to 43 + 2 weeks postmenstrual age. Following both induced and spontaneous right wrist movements, we saw consistent positive blood oxygen level–dependent functional responses in the contralateral (left) primary somatosensory and motor cortices. In addition, we saw a maturational trend toward faster, higher amplitude, and more spatially dispersed functional responses; and increasing integration of the ipsilateral hemisphere and sensori-motor associative areas. We also found that interhemispheric functional connectivity was significantly related to ex-utero exposure, suggesting the influence of experience-dependent mechanisms. At term equivalent age, we saw a decrease in both response amplitude and interhemispheric functional connectivity, and an increase in spatial specificity, culminating in the establishment of a sensori-motor functional response similar to that seen in adults.