Circulating microparticles and risk of venous thromboembolism
Circulating microparticles and risk of venous thromboembolism
复制标题
DOI：
10.1016/j.thromres.2011.08.020
复制
发表时间：
2012-05-01
影响因子：
7.5
通讯作者：
Mannucci, Pier Mannuccio
中科院分区：
文献类型：
--
作者：
Bucciarelli, Paolo;Martinelli, Ida;Mannucci, Pier Mannuccio
引言：循环微粒（MP）可能引发高凝状态，导致血栓性并发症。他们与静脉血栓栓塞（VTE.Materials and Methods）的数据很少，不一致：要调查是否高水平的MP与静脉血栓栓塞的风险增加，我们进行了病例对照研究，对186例患者的第一次，客观诊断，发作静脉血栓栓塞和418名健康对照。通过流式细胞术测量循环MP的血浆水平。结果：患者血浆总MP的中位水平高于对照组（2184/μ L vs 1769/μ L，p
Introduction: Circulating microparticles (MPs) may trigger a hypercoagulable state, leading to thrombotic complications. Data on their association with venous thromboembolism (VTE) are few and inconsistent.Materials and methods: To investigate whether or not high levels of MPs are associated with an increased risk of VTE, we carried out a case-control study on 186 patients with a first, objectively diagnosed, episode of VTE and 418 healthy controls. Plasma levels of circulating MPs were measured by flow cytometry.Results: Patients had higher median plasma levels of total MPs than controls (2184 per mu L vs 1769 per mu L, p