The state and responsiveness of the renin-angiotensin-aldosterone system in patients with type II diabetes mellitus
The state and responsiveness of the renin-angiotensin-aldosterone system in patients with type II diabetes mellitus
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DOI：
10.1016/s0895-7061(98)00265-9
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发表时间：
1999-04-01
影响因子：
3.2
通讯作者：
Hollenberg, NK
中科院分区：
文献类型：
--
作者：
Price, DA;De'Oliveira, JMF;Hollenberg, NK
We have recently reported a combination of renal features that suggests independent angiotensin-mediated control of the renal circulation in the majority of hypertensive patients with type II diabetes. To ascertain whether other tissue elements of the renin-angiotensin-aldosterone system (RAAS) also were activated, we examined the adrenal response to angiotensin II (AngII) infusion on a low salt diet. We assessed also the renin response to the upright position in patients on a low salt diet and renin suppression in patients an a high salt diet. We compared responses in 42 hypertensive patients with type II diabetes (53.1 +/- 1.4 years, mean +/- SEM), 25 healthy controls (52.6 +/- 4.4 years); and 137 essential hypertensives without diabetes (43.3 +/- 1.2 years). A low renin state, defined as a plasma renin activity (PRA)
