Oxime-mediated facile access to 5-methylisoxazoles and applications in the synthesis of valdecoxib and oxacillin.
Oxime-mediated facile access to 5-methylisoxazoles and applications in the synthesis of valdecoxib and oxacillin.
复制标题
DOI：
10.1021/ol502246t
复制
发表时间：
2014-09
期刊：
影响因子：
5.2
通讯作者：
Kui Dong;Haitao Qin;Xing-Xing Bao-Xing;Feng Liu;Chen Zhu
中科院分区：
文献类型：
--
作者：
Kui Dong;Haitao Qin;Xing-Xing Bao-Xing;Feng Liu;Chen Zhu
介绍了一种钯催化的肟介导的未活化烯烃官能化反应合成5-甲基异恶唑的方法。该反应以中等至良好的产率提供各种5-甲基异恶唑。为了进一步证明该方法的实用性，报道了伐地考昔和苯唑西林的快速合成。
A palladium-catalyzed efficient synthesis of 5-methylisoxazoles via oxime-mediated functionalization of unactivated olefins is described. The reaction affords a variety of 5-methylisoxazoles in moderate to good yields. To further demonstrate the utility of the method, the rapid synthesis of valdecoxib and oxacillin is reported.