Toll-like receptors: linking innate and adaptive immunity
Toll-like receptors: linking innate and adaptive immunity
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DOI：
10.1016/j.micinf.2004.08.018
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发表时间：
2004-12-01
影响因子：
5.8
通讯作者：
Medzhitov, R
中科院分区：
文献类型：
--
作者：
Pasare, C;Medzhitov, R
免疫系统对微生物感染的检测和反应在很大程度上取决于一个称为Toll样受体（TLR）的模式识别受体家族。这些受体识别来自各种病原体的保守分子产物，包括革兰氏阳性和阴性细菌、DNA和RNA病毒、真菌和原生动物。TLR对配体的识别导致一系列信号传导事件，导致诱导杀死病原体所必需的急性反应。TLR还负责诱导树突状细胞成熟，这是启动适应性免疫应答的责任和必要条件。尽管TLR控制适应性免疫的诱导，但目前尚不清楚个体TLR如何适当地定制应答以有利于宿主。(C)2004年，Elsevier SAS。All rights reserved.
Detection of and response to microbial infections by the immune system depends largely on a family of pattern-recognition receptors called Toll-like receptors (TLRs). These receptors recognize conserved molecular products derived from various classes of pathogens, including Gram-positive and negative bacteria, DNA and RNA viruses, fungi and protozoa. Recognition of ligands by TLRs leads to a series of signaling events resulting in induction of acute responses necessary to kill the pathogen. TLRs are also responsible for the induction of dendritic, cell maturation, which is responsible and necessary for initiation of adaptive immune responses. Although TLRs control induction of adaptive immunity, it is not clear at this point how responses are appropriately tailored by individual TLRs to the advantage of the host. (C) 2004 Elsevier SAS. All rights reserved.