Pholcodine exposure raises serum IgE in patients with previous anaphylaxis to neuromuscular blocking agents
Pholcodine exposure raises serum IgE in patients with previous anaphylaxis to neuromuscular blocking agents
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福尔可定暴露会导致既往对神经肌肉阻滞剂过敏的患者血清 IgE 升高
DOI：
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
H. Öman
中科院分区：
文献类型：
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作者：
T. Harboe;S. Johansson;E. Florvaag;E. Florvaag;H. Öman
背景：神经肌肉阻滞剂（NMBA）可通过与季铵离子表位结合的免疫球蛋白E（IgE）抗体引起过敏反应。 这些表位存在于许多常见的化学品和药物中，理论上，暴露于这些表位在促进过敏反应的IgE致敏性的发展和维持中可能是重要的。福尔可定就是这样一种药物，在最近的一项初步研究中，它显示出在两个IgE致敏个体中诱导血清IgE水平显著升高。本研究探讨了福尔可定暴露对既往诊断为IgE介导的NMBA过敏反应人群中IgE的影响。
Background: Neuromuscular blocking agents (NMBAs) can cause anaphylaxis through immunoglobulin E (IgE) antibodies that bind quaternary ammonium ion epitopes. These epitopes are present in numerous common chemicals and drugs, exposure to which, theoretically, could be of importance in the development and maintenance of the IgE sensitization promoting allergic reactions. Pholcodine is one such drug, which in a recent pilot study was shown to induce a remarkable increase in serum IgE levels in two IgE‐sensitized individuals. The present study explores the effect of pholcodine exposure on IgE in a population with previously diagnosed IgE‐mediated anaphylaxis towards NMBAs.