Thymus in Experimental Carcinogenesis of the Prostate Gland
Thymus in Experimental Carcinogenesis of the Prostate Gland
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DOI：
10.1007/s10517-014-2652-4
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发表时间：
2014-10-01
影响因子：
0.7
通讯作者：
Larionov, P. M.
中科院分区：
文献类型：
--
作者：
Borodin, Yu. I.;Lomshakov, A. A.;Larionov, P. M.
我们研究了将埃利希腹水瘤细胞移植到CBA小鼠前列腺中后，前列腺、胸腺和淋巴结的结构变化。在实验第5天，腺体中的血管和淋巴管数量减少;结缔组织成分和腺组织的百分比以及胸腺中免疫母细胞的数量增加。在第18天，肿瘤中的血管数量减少;胸腺中皮质和腺组织的宽度增加，而免疫母细胞的数量减少。在第28天，观察到肿瘤浸润和基质中淋巴管数量增加;实质减少，胸腺中结缔组织面积增加。这些结构变化表明，在前列腺癌变过程中，胸腺意外退化。
We studied structural changes in the prostate gland, thymus, and lymph nodes in CBA mice after transplantation of Ehrlich ascites tumor cells into the prostate gland. On experimental day 5, the number of blood and lymph vessels decreased in the gland; the percentage of connective tissue elements and glandular tissue and the number of immunoblasts in the thymus increased. On day 18, the number of blood vessels in the tumor decreased; the width of the cortex and glandular tissue increased in the thymus, while the number of immunoblasts was reduced. On day 28, tumor infiltration and increased number of lymphatic vessels in its stroma were observed; parenchyma was reduced, and the area of the connective tissue increased in the thymus. These structural changes indicated the development of accidental involution of the thymus during carcinogenesis of the prostate.