HMGB1 in cancer: good, bad, or both?
HMGB1 in cancer: good, bad, or both?
复制标题
DOI：
10.1158/1078-0432.ccr-13-0495
复制
发表时间：
2013-08-01
期刊：
影响因子：
--
通讯作者：
Tang D
中科院分区：
文献类型：
--
作者：
Kang R;Zhang Q;Zeh HJ 3rd;Lotze MT;Tang D
40年前，高迁移率族蛋白1（HMGB1）在小牛胸腺中被发现，并根据其在聚丙烯酰胺凝胶中的电泳迁移率而命名。现在，我们知道HMGB1具有双重功能。在细胞内，HMGB1是一种高度保守的染色体蛋白，充当DNA伴侣。在细胞外，HMGB1是一种典型的损伤相关分子模式，与细胞因子、趋化因子和生长因子共同作用。在肿瘤发展和癌症治疗过程中，HMGB1通过调节多种信号通路，包括炎症、免疫、基因组稳定性、增殖、转移、代谢、凋亡和自噬，在促进细胞存活和死亡方面发挥矛盾的作用。在这里，我们回顾了目前的知识HMGB1的致癌和肿瘤抑制作用和潜在的策略，针对HMGB1的预防和治疗癌症。
Forty years ago, high mobility group box 1 (HMGB1) was discovered in calf thymus and named according to its electrophoretic mobility in polyacrylamide gels. Now, we know that HMGB1 performs dual functions. Inside the cell, HMGB1 is a highly conserved chromosomal protein acting as a DNA chaperone. Outside of the cell, HMGB1 is a prototypical damage-associated molecular pattern, acting with cytokine, chemokine, and growth factor. During tumor development and in cancer therapy, HMGB1 has been reported to play paradoxical roles in promoting both cell survival and death by regulating multiple signaling pathways, including inflammation, immunity, genome stability, proliferation, metastasis, metabolism, apoptosis, and autophagy. Here, we review the current knowledge of both HMGB1’s oncogenic and tumor suppressive roles and the potential strategies that target HMGB1 for the prevention and treatment of cancer.