The Autism Diagnostic Observation Schedule-Toddler Module: A New Module of a Standardized Diagnostic Measure for Autism Spectrum Disorders
The Autism Diagnostic Observation Schedule-Toddler Module: A New Module of a Standardized Diagnostic Measure for Autism Spectrum Disorders
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DOI：
10.1007/s10803-009-0746-z
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发表时间：
2009-09-01
影响因子：
3.9
通讯作者：
Lord, Catherine
中科院分区：
文献类型：
--
作者：
Luyster, Rhiannon;Gotham, Katherine;Lord, Catherine
自闭症诊断观察表（ADOS; Lord等人，J Autism Dev Disord，30（3）：205-223，2000）被广泛接受为“金标准”诊断工具，但其对非常年幼的儿童的效用有限。目前项目的目的是修改ADOS，以便用于30个月以下的儿童。在360项评估中使用了改良的ADOS，即ADOS幼儿模块（或模块T）。参与者包括182名最佳估计诊断为ASD、非谱系发育迟缓或典型发育的儿童。根据其区分诊断组的能力选择最终一组方案和算法项。传统的算法“截断点”方法具有较高的灵敏度和特异性，提出了一种新的关注范围方法。
The Autism Diagnostic Observation Schedule (ADOS; Lord et al., J Autism Dev Disord, 30(3):205-223, 2000) is widely accepted as a "gold standard" diagnostic instrument, but it is of restricted utility with very young children. The purpose of the current project was to modify the ADOS for use in children under 30 months of age. A modified ADOS, the ADOS Toddler Module (or Module T), was used in 360 evaluations. Participants included 182 children with best estimate diagnoses of ASD, non-spectrum developmental delay or typical development. A final set of protocol and algorithm items was selected based on their ability to discriminate the diagnostic groups. The traditional algorithm "cutoffs" approach yielded high sensitivity and specificity, and a new range of concern approach was proposed.