PROPERTIES OF RARELY ENCOUNTERED TYPES OF GANGLION-CELLS IN CATS RETINA AND AN OVERALL CLASSIFICATION
PROPERTIES OF RARELY ENCOUNTERED TYPES OF GANGLION-CELLS IN CATS RETINA AND AN OVERALL CLASSIFICATION
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DOI：
10.1113/jphysiol.1974.sp010618
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发表时间：
1974-01-01
影响因子：
5.5
通讯作者：
LEVICK, WR
中科院分区：
文献类型：
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作者：
CLELAND, BG;LEVICK, WR
1. 在960个猫视网膜神经节细胞的参考样本中，73个细胞的接受野偏离了同心中心-环绕模式。2. 子集分为五类：局部边缘检测器，方向选择细胞，颜色编码细胞，均匀性检测器，边缘抑制偏离中心细胞。3. 局部边缘检测器（45）对黑色和白色小目标的离心和向心运动具有径向对称的响应模式，具有沉默抑制环绕和低或零维持放电的开关接受野。他们的操作可以解释为检测一个局限于视野的小区域的对比边界。4. 有了方向选择单元（11），就有可能在感受野中找到一条轴线，沿着这条轴线，黑色或白色的小目标在相反的方向运动时可以得到截然不同的反应。5. 颜色单元（6个）大多为单一对手类型，具有来自蓝敏感锥细胞的兴奋性输入和来自长波锥细胞的抑制性输入。这两种投入同时存在于该领域的中心，任何一种投入在空间上都可以比另一种投入更广泛。一个例子在暗离子条件下换成了棒输入，另一个没有。6. 均匀性检测器（五个）有一个轻快的保持放电，被所有形式的视觉刺激暂时减少或取消。7. 边缘抑制离中心单元（三个）表现得像小目标和精细光栅的均匀性检测器，但像大目标的离中心环绕单元。他们的感受野由三个同心区域组成：一个小的中央边缘抑制区；更大的无反应区；还有一个外围的无反应环。8. 有人认为，上述生理类型属于形态异质性的一类细胞称为γ细胞。这一论点是基于接受野和树突状树的大小相似，以及轴突比持续快速和短暂快速神经节细胞的轴突更薄的证据。9. 本文所发展的猫视网膜神经节细胞的生理分类与前文的分类总结在表10中。现在看来，猫和兔在它们的神经节细胞中具有质量相似的接受野类型补体；不同之处在于不同类别的数量表达。
1. In a reference sample of 960 cat retinal ganglion cells, seventy-three had receptive fields departing from the concentric centre—surround pattern. 2. Five classes were distinguished among the subset: local edge detectors, direction-selective cells, colour-coded cells, uniformity detectors, edge inhibitory off-centre cells. 3. Local edge detectors (forty-five) possessed a radially symmetrical pattern of responses to both centrifugal and centripetal movements of both black and white small targets, an on—off receptive field with a silent inhibitory surround and a low or zero maintained discharge. Their operation could be interpreted as the detection of a contrasting border confined to a small region of the visual field. 4. With direction-selective units (eleven) it was possible to find an axis through the receptive field along which sharply different responses could be obtained for opposite directions of movement of small black or white targets. 5. Colour units (six) were mostly of the single opponent type having excitatory input from blue-sensitive cones and inhibitory input from long wave-length cones. Both inputs coexisted at the centre of the field and either could be spatially more extensive than the other. One example changed over to rod input under scotopic conditions, another did not. 6. Uniformity detectors (five) had a brisk maintained discharge which was reduced or abolished temporarily by all forms of visual stimulation. 7. Edge inhibitory off-centre units (three) behaved like uniformity detectors for small targets and fine gratings but like off-centre on-surround units for large targets. Their receptive fields consisted of three concentric regions: a small sized, central edge inhibitory region; a larger zone of off-responsiveness; and an outlying annulus of on-responsiveness. 8. It is argued that the above physiological types belong to the morphologically heterogeneous class of cells called γ cells. The argument is based on similarity in the sizes of receptive fields and dendritic trees and on evidence that the axons are thinner than those of the brisk-sustained and brisk-transient ganglion cells. 9. The physiological classification of cat retinal ganglion cells developed in this paper and the preceding one is summarized in a Table. 10. It now appears that cat and rabbit possess a qualitatively similar complement of receptive field types among their ganglion cells; the differences reside in the quantitative expression of the various classes.