ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism
ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism
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DOI：
10.1126/science.289.5477.295
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发表时间：
2000-07-14
期刊：
影响因子：
56.9
通讯作者：
Memelink, J
中科院分区：
文献类型：
--
作者：
van der Fits, L;Memelink, J
植物中许多种类的次生代谢物的生物合成是由应激激素茉莉酸酯诱导的。通过转移DNA激活标签技术，从长春花中分离出了ORCA3基因，它是一种对茉莉酸酯有响应的APETALA2（AP2）结构域转录因子。Orca3的过表达导致了几种代谢物生物合成基因表达增强，进而使萜类吲哚生物碱的积累增加。茉莉酸酯响应的AP2结构域转录因子对代谢物生物合成基因的调控可能将植物的应激反应与代谢变化联系起来。
Biosynthesis of many classes of secondary metabolites in plants is induced by the stress hormone jasmonate. The gene for ORCA3, a jasmonate-responsive APETALA2 (AP2)-domain transcription factor from Catharanthus roseus, was isolated by transferred DNA activation tagging. Orca3 overexpression resulted in enhanced expression of several metabolite biosynthetic genes and, consequently, in increased accumulation of terpenoid indole alkaloids, Regulation of metabolite biosynthetic genes by jasmonate-responsive AP2-domain transcription factors may link plant stress responses to changes in metabolism.