The early stages of duplicate gene evolution
The early stages of duplicate gene evolution
复制标题
DOI：
10.1073/pnas.2535513100
复制
发表时间：
2003-12-23
影响因子：
11.1
通讯作者：
Purugganan, MD
中科院分区：
文献类型：
--
作者：
Moore, RC;Purugganan, MD
基因重复是基因组和遗传系统进化的主要驱动力之一。基因重复占真核基因组基因的 8-20%，基因重复率估计为每百万年每个基因 0.2% 至 2%。重复基因被认为是建立新基因功能和产生进化新颖性的主要机制，但人们对重复基因对进化的早期阶段知之甚少。例如，尚不清楚在多大程度上是选择（而不是中性遗传漂变）驱动了重复基因座的固定和早期进化。对拟南芥基因组中最近复制的基因的分析表明，祖先和/或复制基因拷贝中的核苷酸多态性水平显着降低，这表明选择性扫描伴随着这些复制基因对进化的初始阶段。我们的结果支持了最近的理论工作，该工作表明重复基因对的命运可能在重复基因进化的初始阶段决定，并且正选择在重复核基因的早期历史的进化动力学中发挥着重要作用。
Gene duplications are one of the primary driving forces in the evolution of genomes and genetic systems. Gene duplicates account for 8-20% of the genes in eukaryotic genomes, and the rates of gene duplication are estimated at between 0.2% and 2% per gene per million years. Duplicate genes are believed to be a major mechanism for the establishment of new gene functions and the generation of evolutionary novelty, yet very little is known about the early stages of the evolution of duplicated gene pairs. It is unclear, for example, to what extent selection, rather than neutral genetic drift, drives the fixation and early evolution of duplicate loci. Analysis of recently duplicated genes in the Arabidopsis thaliana genome reveals significantly reduced species-wide levels of nucleotide polymorphisms in the progenitor and/or duplicate gene copies, suggesting that selective sweeps accompany the initial stages of the evolution of these duplicated gene pairs. Our results support recent theoretical work that indicates that fates of duplicate gene pairs may be determined in the initial phases of duplicate gene evolution and that positive selection plays a prominent role in the evolutionary dynamics of the very early histories of duplicate nuclear genes.