Experimental animal models for rheumatoid arthritis
Experimental animal models for rheumatoid arthritis
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DOI：
10.1080/08923973.2018.1434793
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发表时间：
2018-01-01
影响因子：
3.3
通讯作者：
Prabhavalkar, Kedar S.
中科院分区：
文献类型：
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作者：
Choudhary, Narayan;Bhatt, Lokesh K.;Prabhavalkar, Kedar S.
类风湿性关节炎（RA）是一种病因不明的自身免疫性系统性疾病，其特征是慢性炎症和免疫细胞的滑膜浸润。RA与预期寿命和生活质量下降有关。动物模型的建立大大简化了RA的研究，有助于我们研究涉及炎症、免疫耐受和自身免疫的复杂系统。具有经证实的人类疗效可预测性跟踪记录的RA动物模型包括：大鼠和小鼠中II型胶原诱导的关节炎、大鼠中佐剂诱导的关节炎和几个种属中抗原诱导的关节炎。RA新疗法的开发需要临床观察和动物模型研究之间的相互作用。然而，每种模式都有不同的机制来驱动疾病的表达;在为要研究的科学问题做出适当选择时，应该仔细评估每种模式的好处。在这篇综述文章中，我们将重点介绍沿着遗传模型在不同物种中诱导的关节炎动物模型。综述还讨论了与人类RA的相似性和差异性。
Rheumatoid Arthritis (RA) is an autoimmune systemic disorder of unknown etiology and is characterized by chronic inflammation and synovial infiltration of immune cells. RA is associated with decreased life expectancy and quality of life. The research on RA is greatly simplified by animal models that help us to investigate the complex system involving inflammation, immunological tolerance and autoimmunity. The animal models of RA with a proven track record of predictability for efficacy in humans include: collagen type II induced arthritis in rats as well as mice, adjuvant induced arthritis in rats and antigen induced arthritis in several species. The development of novel treatments for RA requires the interplay between clinical observations and studies in animal models. However, each model features a different mechanism driving the disease expression; the benefits of each should be evaluated carefully in making the appropriate choice for the scientific problem to be investigated. In this review article, we focus on animal models of arthritis induced in various species along with the genetic models. The review also discussed the similarity and dissimilarities with respect to human RA.