Lung tumor markers of cytokeratin origin: an overview
Lung tumor markers of cytokeratin origin: an overview
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DOI：
10.1016/s0169-5002(01)00347-6
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发表时间：
2001-12-01
期刊：
影响因子：
5.3
通讯作者：
Ferrigno, D
中科院分区：
文献类型：
--
作者：
Buccheri, G;Ferrigno, D
肺肿瘤标记物包括癌胎儿蛋白、结构蛋白及其片段、酶、膜抗原、多肽和非多肽激素。细胞角蛋白(Cell keratins，CH)是一种众所周知的结构蛋白，其降解会产生可溶片段，可在患者的血液中检测到，并能够标记癌症。其中，组织多肽抗原(TPA)、组织多肽特异性抗原(TPS)和细胞角蛋白-19片段(Cyfra 21-1)是研究最多的CK片段复合体。本文将对这些物质的生物学特性和临床特性作一综述，强调它们在外周血中的浓度可能反映肿瘤的质量、癌细胞的裂解率以及其他潜在的不利的肿瘤特性。检测血液中CK片段的浓度是一种简便有效的肺癌评估和监测临床进展的方法。(C)2001年。爱思唯尔爱尔兰科学有限公司，版权所有。
Lung tumor markers fall into several categories including oncofetal proteins, structural proteins and their fragments, enzymes, membrane antigens, peptide and non-peptide hormones. Cytokeratins (Ch) are well known structural proteins whose degradation gives rise to soluble fragments, measurable in the blood of patients and capable of cancer marking. Among them, Tissue Polypeptide Antigen (TPA), Tissue Polypeptide-Specific Antigen (TPS) and Cytokeratin-19-Fragments (Cyfra 21-1) are the most studied CK fragments' complexes. This article will review biological characteristics and clinical properties of these substances, emphasizing as their concentration in the peripheral blood might reflect the mass of tumor, the rate of cancer cell lysis, and other potentially unfavorable tumor characteristics. Assaying the concentration of CK fragments in the blood is an easy and effective way to assess lung cancer and monitor its clinical evolution. (C) 2001. Elsevier Science Ireland Ltd. All rights reserved.