Occult malignant breast lesions in 114 patients: relationship to age and the presence of microcalcifications.
Occult malignant breast lesions in 114 patients: relationship to age and the presence of microcalcifications.
复制标题
114 名患者的隐匿性恶性乳腺病变：与年龄和微钙化存在的关系。
作者：
George Hermann;Cynthia L. Janus;Ira Schwartz;A. Papatestas;D. Hermann;Jack G. Rabinowitz
本研究评估了352例年龄在30-85岁之间的患者的钼靶X线检查结果，这些患者接受了点定位和活检，以评估不可触及的乳腺异常。114例活检时发现结核。钼靶X线表现（特别是，是否存在成组的微钙化、肿块或两者）与患者年龄和组织学结果（特别是，病理变化是否为浸润性或非浸润性）相关。恶性疾病的发病率随着年龄的增长而直接增加。100%的患者可见成组微钙化作为恶性肿瘤的唯一指标（7/7）30-39岁年龄组的患者中，64%在40-49岁年龄组中，37%的人（28人中有18人）在50-59岁年龄组中，30%（23人中有7人），在60-69岁年龄组中，30%（23人中有7人），在70-85岁年龄组中，23%（26人中有6人）。在49个仅表现为微钙化的肿瘤中，34个（69%）是非浸润性的。发现成组的微钙化应积极调查，因为它可能表明非浸润性癌在早期阶段，当治愈的潜力是最大的。
This study evaluates the mammographic findings in 352 patients, aged 30-85 years, who underwent spot localization and biopsy for evaluation of nonpalpable breast abnormalities. Malignancy was found at biopsy in 114 cases. The mammographic appearance (specifically, whether grouped microcalcifications, mass, or both were present) was correlated with patient age and histologic findings (specifically, whether the pathologic changes were infiltrating or noninfiltrating in nature). The prevalence of malignant conditions increased directly with age. The presence of grouped microcalcifications as the sole indicator of malignancy was seen in 100% (seven of seven) of the patients in the 30-39-year age group, 64% (18 of 28) in the 40-49-year age group, 37% (11 of 30) in the 50-59-year age group, 30% (seven of 23) in the 60-69-year age group, and 23% (six of 26) in the 70-85-year age group. Of the 49 tumors that were manifested solely as microcalcifications, 34 (69%) were noninfiltrating. The finding of grouped microcalcifications should be aggressively investigated, since it may indicate noninfiltrating carcinoma in an early stage, when the potential for cure is greatest.