Lack of association of human G-protein β3 subunit variant with hypertension in Japanese workers
Lack of association of human G-protein β3 subunit variant with hypertension in Japanese workers
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DOI：
10.1097/00004872-200403000-00011
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发表时间：
2004-03-01
影响因子：
4.9
通讯作者：
Nogawa, K
中科院分区：
文献类型：
--
作者：
Suwazono, Y;Okubo, Y;Nogawa, K
目的 探讨日本工人高血压与 G 蛋白 03 亚基基因 C825T 多态性的关系。方法 本研究采用 Logistic 回归分析和多元回归分析，探讨在考虑年龄、体重指数、血液化学和生活方式等因素时，C825T 多态性是否与高血压或血压独立相关。目标对象是从单个公司的3834名男性和2591名女性工人中选出的1452名男性和1169名女性工人。高血压的定义是收缩压大于或等于140毫米汞柱和/或舒张压大于或等于90毫米汞柱，或正在服用抗高血压药物。根据白种人的等位基因频率，该研究的功效估计为男性为 83%，女性为 41%。 结果 高血压男性（CC = 58，CT = 135，TT = 63）和女性（CC = 20，CT = 36，TT = 20）中 C825T 的基因型分布与血压正常男性（CC = 300，CT）没有显着差异。 = 614，TT = 282）或女性（CC = 274，CT = 602，TT = 217）。两性的等位基因分布没有显着差异。多元Logistic回归分析显示，基因型与高血压无显着相关性，而高血压与年龄、高血压家族史、体重指数、红细胞压积、血小板计数、γ-谷氨酰转肽酶(γ-GTP)、尿酸有显着相关。使用单因素方差分析和多元回归的数据分析表明，C825T 等位基因对收缩压、舒张压或平均血压没有显着影响。 结论 这项研究表明，C825T 多态性不是日本人高血压或血压的重要因素。因此，当试图预防普通日本人群的高血压时，针对这种多态性不太可能有益。 (C) 2004 年利平科特·威廉姆斯·威尔金斯。
Objective To examine the association between hypertension and the C825T polymorphism in the G-protein 03 subunit gene in Japanese workers.Methods This study used logistic regression analysis and multiple regression analyses to investigate whether the C825T polymorphism was associated independently with hypertension or blood pressure when factors such as age, body mass index, blood chemistry and lifestyle were taken into consideration. The target subjects were 1452 male and 1169 female workers selected from 3834 male and 2591 female workers in a single company. Hypertension was defined as a systolic blood pressure greater than or equal to 140 mmHg and/or diastolic blood pressure greater than or equal to 90 mmHg, or taking anti hypertensive medication. The power of the study was estimated as 83% for males and 41% for females based on allelic frequencies in Caucasians.Results Genotype distributions for C825T in hypertensive males (CC = 58, CT = 135, TT = 63) and females (CC = 20, CT = 36, TT = 20) were not significantly different from normotensive males (CC = 300, CT = 614, TT = 282) or females (CC = 274, CT = 602, TT = 217), respectively. Allele distributions were not significantly different in either sex. Multiple logistic regression analysis showed that genotype was not associated significantly with hypertension, whereas there was a significant relationship between hypertension and age, family history of hypertension, body mass index, hematocrit, platelet count, gamma-glutamyl transpeptidase (gamma-GTP) and uric acid. Data analysis using one-way analysis of variance and multiple regression showed that the C825T allele had no significant influence on either systolic, diastolic or mean blood pressure.Conclusions This study indicates that the C825T polymorphism is not a significant factor for hypertension or blood pressures in Japanese people. Targeting of this polymorphism is therefore unlikely to be beneficial when attempting to prevent hypertension in the general Japanese population. (C) 2004 Lippincott Williams Wilkins.