The environment, the tick, and the pathogen - It is an ensemble.
The environment, the tick, and the pathogen - It is an ensemble.
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DOI：
10.3389/fcimb.2022.1049646
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发表时间：
2022
影响因子：
5.7
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中科院分区：
文献类型：
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肩胛硬蜱是莱姆病的主要传播媒介之一。地理分布的I。美国东北部和中北部特有的肩胛骨炎正在向南扩展到格鲁吉亚和德克萨斯，并向北扩展到加拿大，并造成了迫在眉睫的公共卫生问题。蜱传疾病的流行和传播受到微生物、生态和环境等多种因素的相互作用的影响。分子生物学研究主要集中在蜱-宿主和病原体之间的相互作用上，这些相互作用决定了蜱能否成功获得病原体并将其传播给哺乳动物宿主。在这篇综述中，我们提请注意影响蜱生物学和蜱-病原体相互作用的其他关键环境因素。重点是B。burgdorferi我们强调了非生物因素如温度和湿度以及生物因素如蜱虫在其对蜱虫的宿主期和非宿主期期间暴露于的环境微生物群和感染流行率的相互作用。对这种相互作用的分子理解对于获得对蜱-病原体相互作用的生物学的新见解以及开发控制蜱和蜱传播B的新方法至关重要。莱姆病的病原体。
Ixodes scapularis is one of the predominant vectors of Borrelia burgdorferi, the agent of Lyme disease in the USA. The geographic distribution of I. scapularis, endemic to the northeastern and northcentral USA, is expanding as far south as Georgia and Texas, and northwards into Canada and poses an impending public health problem. The prevalence and spread of tick-borne diseases are influenced by the interplay of multiple factors including microbiological, ecological, and environmental. Molecular studies have focused on interactions between the tick-host and pathogen/s that determine the success of pathogen acquisition by the tick and transmission to the mammalian host. In this review we draw attention to additional critical environmental factors that impact tick biology and tick-pathogen interactions. With a focus on B. burgdorferi we highlight the interplay of abiotic factors such as temperature and humidity as well as biotic factors such as environmental microbiota that ticks are exposed to during their on- and off-host phases on tick, and infection prevalence. A molecular understanding of this ensemble of interactions will be essential to gain new insights into the biology of tick-pathogen interactions and to develop new approaches to control ticks and tick transmission of B. burgdorferi, the agent of Lyme disease.