Nostopeptins A and B, elastase inhibitors from the cyanobacterium Nostoc minutum
Nostopeptins A and B, elastase inhibitors from the cyanobacterium Nostoc minutum
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DOI：
10.1021/np960649a
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发表时间：
1997-02-01
影响因子：
5.1
通讯作者：
Yamaguchi, K
中科院分区：
文献类型：
--
作者：
Okino, T;Qi, S;Yamaguchi, K
从培养的淡水蓝藻发菜(NIES-26)中分离得到诺维菌素A和B。根据二维核磁共振数据和化学降解确定了它们的结构。这些含有AHP(3-氨基-6-羟基-2-哌啶酮)的环状多肽对弹性蛋白酶和胰凝乳酶有明显的抑制作用。
Nostopeptins A and B were isolated from the cultured freshwater cyanobacterium Nostoc minutum (NIES-26). Their structures were elucidated on the basis of 2D NMR data and chemical degradation. These cyclic depsipeptides containing Ahp (3-amino-6-hydroxy-2-piperidone) inhibited elastase and chymotrypsin potently.