Probucol-Oxidized Products, Spiroquinone and Diphenoquinone, Promote Reverse Cholesterol Transport in Mice
Probucol-Oxidized Products, Spiroquinone and Diphenoquinone, Promote Reverse Cholesterol Transport in Mice
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DOI：
10.1161/atvbaha.115.306376
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发表时间：
2016-04-01
影响因子：
8.7
通讯作者：
Ikewaki, Katsunori
中科院分区：
文献类型：
--
作者：
Yakushiji, Emi;Ayaori, Makoto;Ikewaki, Katsunori
目的普罗布考氧化产物螺醌和联苯醌可通过抑制ATP结合盒转运体A1的降解而增加细胞胆固醇释放和血浆高密度脂蛋白（HDL）。方法和结果螺醌和联苯醌使ATP结合盒转运体A1蛋白增加（分别为2.8倍和2.6倍，P
Objective Oxidized products of probucol, spiroquinone and diphenoquinone, were shown to increase cell cholesterol release and plasma high-density lipoprotein (HDL) by inhibiting degradation of ATP-binding cassette transporter A1. We investigated whether these compounds enhance reverse cholesterol transport in mice.Approach and Results Spiroquinone and diphenoquinone increased ATP-binding cassette transporter A1 protein (2.8- and 2.6-fold, respectively, P