The Effects of Catecholamines and Drug Treatment on the Fetus and Newborn
The Effects of Catecholamines and Drug Treatment on the Fetus and Newborn
复制标题
儿茶酚胺和药物治疗对胎儿和新生儿的影响
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
H. A. Fox
中科院分区：
文献类型：
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作者：
H. A. Fox
：胎儿在妊娠早期就能产生儿茶酚胺。正常浓度的这些化合物对于胎儿和新生儿的体内平衡以及成功完成从胎儿到新生儿生命的过渡是必要的。胎儿和新生儿应激导致儿茶酚胺水平显著升高，引起大量生理紊乱。虽然胎儿儿茶酚胺是内源性产生的，但母体疾病和焦虑可启动母体儿茶酚胺产生链，导致分娩功能障碍和子宫灌注不足，并通过该机制导致胎儿窘迫。减少产妇焦虑的措施应在分娩管理中占有高度优先地位。虽然非药物方法可能足够，但在选定的情况下，使用中等剂量的镇痛剂可能对胎儿有保护作用。
: The fetus is capable of producing catecholamines from early in gestation. Normal concentrations of these compounds are necessary for fetal and neonatal homeostasis, and for successfully completing the transition from fetal to neonatal life. Fetal and neonatal stress result in marked elevations of catecholamine levels, causing a large number of physiologic derangements. While fetal catecholamines are endogenously produced, maternal illness and anxiety can initiate the chain of maternal catecholamine production, causing dysfunctional labor and uterine hypoperfusion, and through this mechanism, fetal distress. Measures to reduce maternal anxiety should have a high priority in the management of labor. While nonpharmacologic methods may suffice, the use of analgesic agents in moderate doses may be protective to the fetus in selected circumstances.