Does more MnSOD mean more hydrogen peroxide?
Does more MnSOD mean more hydrogen peroxide?
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DOI：
10.2174/187152011795255939
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发表时间：
2011-01
影响因子：
2.8
通讯作者：
L. MacMillan-Crow;J. Crow
中科院分区：
文献类型：
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作者：
L. MacMillan-Crow;J. Crow
超氧化物歧化酶 (SOD) 是一类重要的抗氧化酶，可催化超氧化物转化为过氧化氢和氧气。然后过氧化氢被许多抗氧化酶解毒。一个常见的误解是，MnSOD 水平升高会导致过氧化氢水平升高。在此，我们提供了造成这种混乱的一些潜在原因，以及一些可能的解决方案。提供的数据证明，在一氧化氮存在下，MnSOD 能够利用过氧化氢产生超氧化物和毒性更强的氧化剂过氧亚硝酸盐。
Superoxide dismutases (SODs) are a family of important antioxidant enzymes that catalyze the conversion of superoxide to hydrogen peroxide and oxygen. Hydrogen peroxide is then detoxified by a host of antioxidant enzymes. A common misconception is that the increased MnSOD levels will result in increased hydrogen peroxide levels. Herein we offer some potential reasons for this confusion, as well as some potential resolutions. Data are offered that demonstrate the ability of MnSOD, in the presence of nitric oxide, to utilize hydrogen peroxide to produce superoxide and the more toxic oxidant, peroxynitrite.