Plasma Pentraxin 3 Concentration Increases in Endurance-Trained Men
Plasma Pentraxin 3 Concentration Increases in Endurance-Trained Men
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DOI：
10.1249/mss.0b013e3181e84bce
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发表时间：
2011-01-01
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影响因子：
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通讯作者：
Ajisaka, Ryuichi
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文献类型：
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作者：
Miyaki, Asako;Maeda, Seiji;Ajisaka, Ryuichi
宫崎，A.， S. MAEDA， T. OTSUKI，和R. AJISAKA。耐力训练男性血浆戊烷素3浓度升高。医学科学。体育Exerc。， Vol. 43, No. 1, pp. 12-17, 2011。导读：penttraxin 3 （PTX3）主要由动脉粥样硬化区内皮细胞、巨噬细胞和平滑肌细胞产生，具有保护心脏的作用。耐力运动训练也有保护心脏的作用。然而，定期耐力运动对PTX3的影响尚不清楚。本研究旨在调查耐力训练男性的血浆PTX3浓度是否增加。10名年轻的耐力训练男性和12名年龄和性别匹配的久坐对照组参加了这项研究。方法：测定各组患者血浆PTX3浓度。我们还通过同时使用m型超声和颈总动脉压血压计来确定全身动脉顺应性（SAC），并使用高密度脂蛋白胆固醇（HDLC）作为心脏保护作用的指标。结果：耐力训练男性的最大摄氧量明显高于久坐对照组。耐力训练组SAC和HDLC明显高于久坐对照组（SAC = 1.74 +/- 0.11 vs 1.41 +/- 0.09 mL.mm Hg-1, P < 0.05; HDLC = 70 +/- 5 vs 57 +/- 4 mg.dL, P < 0.05）。耐力训练男性的血浆PTX3浓度明显高于久坐对照组（0.93 +/- 0.11 vs 0.68 +/- 0.06 ng）。mL(-1), P < 0.05)。血浆PTX3浓度与SAC和HDLC呈线性关系。结论：这是第一个揭示耐力训练的个体比久坐的对照组有更高水平的循环PTX3的研究。PTX3可能在耐力运动训练诱导的心脏保护中发挥部分作用。
MIYAKI, A., S. MAEDA, T. OTSUKI, and R. AJISAKA. Plasma Pentraxin 3 Concentration Increases in Endurance-Trained Men. Med. Sci. Sports Exerc., Vol. 43, No. 1, pp. 12-17, 2011. Introduction: Pentraxin 3 (PTX3), which is mainly produced by endothelial cells, macrophages, and smooth muscle cells in the atherosclerotic region, has a cardioprotective effect. Endurance exercise training has also been known to offer cardioprotection. However, the effect of regular endurance exercise on PTX3 is unknown. This study aimed to investigate whether plasma PTX3 concentrations increase in endurance-trained men. Ten young endurance-trained men and 12 age-and gender-matched sedentary controls participated in this study. Methods: We measured plasma PTX3 concentrations of the participants in each group. We also determined systemic arterial compliance (SAC) by using simultaneous M-mode ultrasound and arterial applanation tonometry of the common carotid artery and used HDL cholesterol (HDLC) as an index of cardioprotective effect. Results: Maximal oxygen uptake was significantly higher in the endurance-trained men than that in the sedentary controls. SAC and HDLC were significantly higher in the endurance-trained men than that in the sedentary controls (SAC = 1.74 +/- 0.11 vs 1.41 +/- 0.09 mL.mm Hg-1, P < 0.05; HDLC = 70 +/- 5 vs 57 +/- 4 mg.dL(-1), P < 0.05). Plasma PTX3 concentrations were markedly higher in the endurance-trained men than that in the sedentary controls (0.93 +/- 0.11 vs 0.68 +/- 0.06 ng.mL(-1), P < 0.05). Relationships between plasma PTX3 concentrations and SAC and HDLC were linear. Conclusions: This is the first study revealing that endurance-trained individuals had higher levels of circulating PTX3 than sedentary controls. PTX3 may play a partial role in endurance exercise training-induced cardioprotection.