Investigation of colonic prostaglandins in carcinogenesis in the rat colon
Investigation of colonic prostaglandins in carcinogenesis in the rat colon
复制标题
结肠前列腺素在大鼠结肠癌发生中的研究
DOI：
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发表时间：
1991
影响因子：
3.9
通讯作者：
Itsuo Miyazaki
中科院分区：
文献类型：
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作者：
A. Yamaguchi;T. Ishida;G. Nishimura;M. Katoh;Itsuo Miyazaki
采用直肠注射MNNG诱发大鼠大肠癌模型，测定大肠粘膜前列腺素（PG）含量随时间的变化。对照组中结肠粘膜的PGE 2水平在5周时为20.9±9.7（pg/mg总蛋白），在10周时为25.5 ±9.7，在20周时为26.5±18.1，在40周时为34.8±12.7。MNNG治疗组5周时PGE 2水平为44.7±6.2，10周时为43.1±14.9，20周时为70.1±23.4，40周时为79.7±54.1。因此，在所有周内，MNNG组的非癌粘膜的固有PGE 2水平均显著高于对照组。在40周时，癌病变的PGE 2水平显著高于非癌区域。癌灶中6-keto-PGF_（1 α）、PGF_（2 α）在40周时显著降低，TXB_2显著升高。结果表明，PGE 2在MNNG诱导的大鼠大肠癌发生中作为癌的发生和增殖的促进剂而被牵连。
Large bowel carcinoma was induced in rats by injecting MNNG intrarectally, and changes in the large bowel mucosa prostaglandin (PG) with time were determined. The PGE2 levels of the colonic mucosa in a control group were 20.9±9.7 (pg/mg total protein) at 5 weeks, 25.5 ±9.7 at 10 weeks, 26.5±18.1 at 20 weeks, and 34.8±12.7 at 40 weeks. The PGE2 levels in the MNNG-treated group were 44.7±6.2 at 5 weeks, 43.1±14.9 at 10 weeks, 70.1±23.4 at 20 weeks, and 79.7±54.1 at 40 weeks. The intrinsic PGE2 levels of the noncancerous mucosa were thus significantly higher for the MNNG group than for the control group at all weeks. At 40 weeks, the PGE2 levels of cancer lesions were significantly high compared with those of the noncancerous area. In the cancerous lesions, 6-keto-PGF1α and PGF2α decreased and TXB2 increased significantly at 40 weeks. The observations demonstrated that PGE2 was implicated as a promoter in the development and proliferation of carcinoma in MNNG-induced large bowel carcinogenesis in rats.
鼠 B 细胞白血病 (BCL1) 中的免疫抑制：贴壁细胞在抑制体外初级抗体反应中的作用。
DOI：
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发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Anderson,SA;Isakson,PC;Pure,E;Muirhead,M;Uhr,JW;Vitetta,ES
通讯作者：
Vitetta,ES