Obesity and Oxidative Stress in Older Adults At Risk for Dementia: A Magnetic Resonance Spectroscopy Study.
Obesity and Oxidative Stress in Older Adults At Risk for Dementia: A Magnetic Resonance Spectroscopy Study.
复制标题
有痴呆风险的老年人的肥胖和氧化应激：一项磁共振波谱研究。
DOI：
10.1097/wad.0000000000000434
复制
发表时间：
2021
影响因子：
2.1
通讯作者：
S. Duffy
中科院分区：
文献类型：
--
作者：
Ashlee Turner;C. Hoyos;L. Mowszowski;H. LaMonica;J. Lagopoulos;Marilena M. Demayo;Catriona Ireland;I. Hickie;S. Naismith;S. Duffy
客观的
OBJECTIVE
This study aimed to investigate the relationship between obesity and oxidative stress in older adults at risk for dementia. It also aimed to explore the influence of physical activity on the relationship between obesity and oxidative stress in this at risk cohort.
METHODS
Older adults at risk for dementia underwent comprehensive medical, neuropsychological, and psychiatric assessment. At risk was defined as participants with subjective or mild cognitive impairment. Glutathione was assessed by magnetic resonance spectroscopy in the left hippocampus and the anterior and posterior cingulate cortex. Body mass index (BMI) was calculated and classified as healthy (BMI <25 kg/m2) or overweight/obese (BMI ≥25 kg/m2).
RESULTS
Sixty-five older adults (mean age=66.2 y) were included for analysis. The overweight/obese group had significantly greater glutathione in the hippocampus compared with the healthy weight group (t=-2.76, P=0.008). No significant difference in glutathione was observed between groups in the anterior or posterior cingulate. In the overweight/obese group, a higher BMI was associated with a diabetes diagnosis and lower total time engaging in physical activity (r=-0.36, P=0.025), however, glutathione did not correlate with activity levels across groups.
CONCLUSION
This study demonstrates that changes in in vivo markers of oxidative stress are present in overweight/obese older adults at risk for dementia. Future research should explore the relationship with diabetes and the longitudinal relationship between BMI and oxidative stress, and response to therapeutic interventions.
DOI：
10.1016/j.pathophys.2006.05.004
发表时间：
2006-08-01
期刊：
Pathophysiology : the official journal of the International Society for Pathophysiology
影响因子：
--
作者：
Chauhan, Ved;Chauhan, Abha
通讯作者：
Chauhan, Abha