Artemisinin and plant secondary metabolism
Artemisinin and plant secondary metabolism
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DOI：
10.1007/s11434-015-0987-5
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发表时间：
2016-01
期刊：
影响因子：
18.9
通讯作者：
Xiao-Ya Chen;Zhi-hong Xu
中科院分区：
文献类型：
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作者：
Xiao-Ya Chen;Zhi-hong Xu
1977年3月，一组药理学家和化学家在《中国科学通报》上发表了一篇长达一页的文章，报道了传统中药青蒿中存在的抗疟成分。（sweet wormwood）是一种倍半萜内过氧化物内酯，他们将其命名为青蒿素。女科学家屠呦呦女士是著名的“青蒿素结构协调研究小组”的作者之一。这种新型化合物不仅对氯喹耐药株有效，而且对恶性疟原虫的多药耐药株也有效，它通过内过氧化物基序断裂释放的自由基杀死所有无性阶段的恶性疟原虫，尽管确切的分子作用模式仍不清楚。2004年，世界卫生组织建议以青蒿素为基础的联合疗法作为治疗疟疾的最有效策略。该药物及其衍生物挽救了数百万人的疟疾生命，屠呦呦教授于2015年获得诺贝尔生理学或医学奖。
In March of 1977, a team of pharmacologists and chemists published a one-page article in Chinese Science Bulletin [1], which reports that the antimalarial component present in the traditional Chinese herb Artemisia annua L.(sweet wormwood) is a sesquiterpene endoperoxide lactone, and they named it artemisinin. Mrs. Youyou Tu, a woman scientist, is one of the authors who formed the famous ‘‘coordinating research group for the structure of artemisinin.’’This novel compound is effective against not only chloroquine-resistant but also multidrug-resistant strains of the malarial parasite, Plasmodium falciparum, and it kills P. falciparum of all asexual stages by radicals released from break of the endoperoxide motif, although the exact molecular mode of the action still remains unclear. In 2004, World Health Organization suggested the artemisininbased combination therapies as the most effective strategy for malaria treatment. The drug and its derivatives have saved millions of lives from malaria, and Prof. Youyou Tu received the Nobel Prize in Physiology or Medicine in 2015.