Nonalcoholic fatty liver disease and eGFR levels could be linked by the PNPLA3 I148M polymorphism in children with obesity
Nonalcoholic fatty liver disease and eGFR levels could be linked by the PNPLA3 I148M polymorphism in children with obesity
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DOI：
10.1111/ijpo.12539
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发表时间：
2019-10-01
影响因子：
3.8
通讯作者：
del Giudice, Emanuele Miraglia
中科院分区：
文献类型：
--
作者：
Marzuillo, Pierluigi;Di Sessa, Anna;del Giudice, Emanuele Miraglia
背景：PNPLA3 I148M 多态性对非肥胖非糖尿病成人和组织学证实的非酒精性脂肪性肝病 (NAFLD) 儿童的估计肾小球滤过率 (eGFR) 的调节有影响。目的：本研究的目的是探讨 PNPLA3 I148M 多态性对患有和不患有 NAFLD 的肥胖儿童 eGFR 的影响。方法：我们对 591 名肥胖患者进行了基因分型PNPLA3 I148M 多态性。收集人体测量、生化和仪器数据。 NAFLD 的定义是存在超声检测的肝脏脂肪变性和/或 ALT 水平大于 40 IU/L。 结果：与无 NAFLD 的受试者相比，NAFLD 患者的 eGFR 水平显着降低。无论是否存在 NAFLD，与 PNPLA3 IM 或 II 基因型的儿童相比，PNPLA3 MM 基因型的儿童均表现出较低的 eGFR 水平。 eGFR 方差的一般线性模型，包括性别、肥胖持续时间、PNPLA3 基因型、HOMA、BMI-SDS、LDL-C 和甘油三酯作为协变量，证实仅在 NAFLD 存在的情况下 eGFR 和 PNPLA3 基因型之间存在负相关。结论：与其他基因型相比，肥胖和 PNPLA3 MM 基因型儿童的 eGFR 水平较低，这种多态性对NAFLD 的存在。
Background: PNPLA3 I148M polymorphism has an effect on modulation of estimated glomerular filtration rate (eGFR) in nonobese nondiabetic adults and in children with histologically confirmed nonalcoholic fatty liver disease (NAFLD).Objectives: The objective of the study is to explore the impact of PNPLA3 I148M polymorphism on eGFR in children with obesity with and without NAFLD.Methods: We genotyped 591 patients with obesity for PNPLA3 I148M polymorphism. Anthropometrical, biochemical, and instrumental data were collected. NAFLD was defined by the presence of ultrasound- detected liver steatosis and/or ALT levels greater than 40 IU/L.Results: Patients with NAFLD showed significantly lower eGFR levels compared with subjects without NAFLD. Children with PNPLA3 MM genotype showed lower eGFR levels compared with those with either PNPLA3 IM or II genotypes both in the presence and absence of NAFLD. A general linear model for eGFR variance, including gender, duration of obesity, PNPLA3 genotypes, HOMA, BMI-SDS, LDL-C, and triglycerides as covariates, confirmed an inverse association between eGFR and PNPLA3 genotype only in the presence of NAFLD.Conclusions: Children with obesity and PNPLA3 MM genotype show lower eGFR levels compared with other genotypes, with a major effect of this polymorphism in the presence of NAFLD.