TLR signaling pathway in patients with sepsis
TLR signaling pathway in patients with sepsis
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DOI：
10.1097/shk.0b013e318181af2a
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发表时间：
2008-01-01
期刊：
影响因子：
3.1
通讯作者：
Rigato, Otelo
中科院分区：
文献类型：
--
作者：
Salomao, Reinaldo;Martins, Paulo Sergio;Rigato, Otelo
脓毒症的发病机制涉及宿主和感染微生物之间复杂的相互作用。细菌识别和信号是先天免疫系统细胞的基本功能，并驱动协调的免疫反应。脓毒症更耐人寻味的一个方面是，保护性和破坏性宿主反应是同一过程的一部分，即旨在控制感染过程的炎症反应也强调了脓毒症的许多病理生理事件。Toll样受体(TLRs)在人类中的发现，以及TLR-4作为信号转导内毒素生物活性的受体的早期识别，不仅是脓毒症领域的重大突破，也是整个免疫学领域的重大突破。在这篇文章中，我们旨在回顾TLR在脓毒症中的表达和信号转导。我们的研究结果表明，TLR和其他细胞表面受体在单个核细胞和中性粒细胞上可能受到不同的调节，并且它们在脓毒症的不同阶段是动态调节的。在更严重的疾病形式中，单核细胞中Toll样受体信号基因的表达减少。相比之下，中性粒细胞中上调的基因在败血症的临床谱系中可见。
The pathogenesis of sepsis involves complex interaction between the host and the infecting microorganism. Bacterial recognition and signaling are essential functions of the cells of innate immune systems and drive a coordinated immune response. One of the more intriguing aspects of sepsis is the fact that the protective and damaging host response are part of the same process, that is, the inflammatory response that is aimed to control the infectious process also underscores many of the pathophysiological events of sepsis. The discovery of Toll-like receptors (TLRs) in humans, and the early recognition of TLR-4 as the receptor that signals LPS bioactivity were major breakthroughs not only in the field of sepsis but also in immunology as a whole. In this article, we aimed to review TLR expression and signaling in the context of sepsis. The results obtained by our group show that TLR and other cellular surface receptors may be differently regulated on mononuclear cells and neutrophils, and that they are dynamically modulated across the stages of sepsis. Toll-like receptor signaling gene expression in mononuclear cells is decreased in more severe forms of the disease. In contrast, up-regulated genes are seen along the clinical spectrum of sepsis in neutrophils.