In vivo transrectal imaging of canine prostate with a sensitive and compact handheld transrectal array photoacoustic probe for early diagnosis of prostate cancer
In vivo transrectal imaging of canine prostate with a sensitive and compact handheld transrectal array photoacoustic probe for early diagnosis of prostate cancer
复制标题
使用灵敏紧凑的手持式经直肠阵列光声探头对犬前列腺进行体内经直肠成像，用于前列腺癌的早期诊断
DOI：
10.1364/boe.10.001707
复制
发表时间：
2019-04-01
影响因子：
3.4
通讯作者：
Song, Liang
中科院分区：
文献类型：
--
作者：
Liu, Chengbo;Xing, Muyue;Song, Liang
在这项研究中，我们通过将多个光学元件与经直肠超声(TRUS)换能器阵列集成在一起，构建了一种新型的手持阵列光声探头。光学元件提供激光能量，TRUS用于光声信号检测。与以前报道的探头相比，新的光声探头利用优化的光照明方案来提高激光能量的利用效率，从而提高探头的成像灵敏度。此外，新的探头结构紧凑，便于临床医生操作。我们通过模体研究和模拟前列腺癌条件的活体犬模型研究，验证了这种光声探头用于前列腺癌成像的使用。结果表明，该探头适合临床应用，可用于前列腺癌的早期诊断、靶向图像引导下的活检、术中图像引导下的手术等临床应用。(C)OSA开放获取出版协议条款下的2019年美国光学学会
In this study, we built a novel handheld array photoacoustic probe by integrating multiple optical components with a transrectal ultrasound (TRUS) transducer array. The optical components deliver laser energy and TRUS is used for photoacoustic signal detection. Compared to the previously reported probe, the new photoacoustic probe utilizes an optimized light illumination scheme to enhance the utilization-efficiency of the laser energy, thus improving the imaging sensitivity of the probe. In addition, the new probe is compact and easy to handle for clinicians. We validated the use of this photoacoustic probe for prostate cancer imaging through both phantom studies and in vivo canine model study, which mimics the prostate cancer conditions. The results showed that the probe is suitable for clinical use and can be used in the clinics for several potential clinical applications, including early diagnosis of prostate cancer, targeted image-guided biopsy, and image-guided intra-operative procedure. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement