Gender and COPD in patients attending a pulmonary clinic
Gender and COPD in patients attending a pulmonary clinic
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DOI：
10.1378/chest.128.4.2012
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发表时间：
2005-10-01
期刊：
影响因子：
9.6
通讯作者：
Celli, BR
中科院分区：
文献类型：
--
作者：
de Torres, JP;Casanova, C;Celli, BR
目的：比较COPD患者参加肺科门诊的临床表现的性别差异。材料和方法：我们比较了53名FEV 1匹配的男性和女性参加肺科门诊的COPD患者。我们研究了年龄、吸烟年数、Pao（2）Paco（2）、功能性残气量、体重指数（BMI）、呼吸困难、6分钟步行距离（6 MWD）、健康相关生活质量、合并症的存在以及前一年的病情加重情况。女性更年轻（57岁vs 65岁，p < 0.05），吸烟较少（48包-年vs 69包-年，p < 0.05），Pao更好（2），（74 mm Hg vs 67 min Hg，p < 0.05），Paco较低（2）（40 mm Hg vs 45 min Hg，p < 0.05），BMI较低（25比28，p < 0.05），在过去的一年中更多的恶化（I比0，p < 0.05），和更少的合并症（Charlson评分2比评分4，p < 0.05）比男性。尽管女性患者的FEV 1相同，氧合更好，Paco更好，合并症更少，但她们在步行距离方面表现较差（6 MWD占预测值的百分比，87% vs 105%; p = 0.05），生活质量评分较差（圣乔治呼吸问卷[SGRQ]症状评分，51对41，p < 0.05; SGRQ活动评分，58 vs 47，p < 0.05），呼吸困难程度较高（改良医学研究理事会量表> 2分，28%对6%，p = 0.05）结论：在肺科门诊就诊的COPD患者人群中，COPD的临床表现存在性别相关差异，需要进一步关注。
Objectives: To compare gender differences in the clinical expression of COPD patients attending a pulmonary clinic.Materials and methods: We compared 53 FEV1-matched men and women with COPD attending a pulmonary clinic. We studied age, smoking pack-years history, Pao(2) Paco(2), functional residual capacity, body mass index (BMI), dyspnea, 6-min walk distance (6MWD), health-related quality of life, presence of comorbidities, and exacerbations in the previous year.Results: Women were younger (57 years vs 65 years, p < 0.05), smoked less (48 pack-years vs 69 pack-years, p < 0.05), had better Pao(2), (74 mm Hg vs 67 min Hg, p < 0.05), lower Paco(2) (40 mm Hg vs 45 min Hg, p < 0.05), lower BMI (25 vs 28, p < 0.05), more exacerbations in the last year (I vs 0, p < 0.05), and fewer comorbidities (Charlson score 2 vs score 4, p < 0.05) than men. Even though women had the same FEV1, better oxygenation, better Paco(2), and fewer comorbidities, they performed poorer in walking distance (6MWD percentage of predicted, 87% vs 105%; p = 0.05), had worse quality-of-life scores (Saint George's Respiratory Questionnaire [SGRQ] symptoms score, 51 vs 41, p < 0.05; SGRQ activity score, 58 vs 47, p < 0.05), and had a higher degree of dyspnea (Modified Medical Research Council scale > 2, 28% vs 6%, p = 0.05).Conclusions: In a population of patients with COPD attending a pulmonary clinic, there are gender-related differences in the clinical expression of COPD that need further attention.