INDUCTION OF HEAT-SHOCK PROTEINS ENHANCES MYOCARDIAL AND ENDOTHELIAL FUNCTIONAL RECOVERY AFTER PROLONGED CARDIOPLEGIC ARREST
INDUCTION OF HEAT-SHOCK PROTEINS ENHANCES MYOCARDIAL AND ENDOTHELIAL FUNCTIONAL RECOVERY AFTER PROLONGED CARDIOPLEGIC ARREST
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DOI：
10.1016/0003-4975(94)90385-9
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发表时间：
1994-01-01
影响因子：
4.6
通讯作者：
YACOUB, MH
中科院分区：
文献类型：
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作者：
AMRANI, M;CORBETT, J;YACOUB, MH
本研究的目的是探讨热休克应激后热休克蛋白在长时间心脏骤停后心脏机械和内皮功能恢复中的作用。分离的工作大鼠心脏在4℃下停跳4小时，分为三组：(1)对照组、(2)假处理组和(3)热休克组。缺血后心输出量和内皮功能的恢复率(以缺血前对照的百分比表示)分别为57.8%+/-2.8%和20.8%+/-3.9%、50.9%+/-4.0%和26.3%+/-5.9%、74.0%+/-2.4%和51.2%+/-8.0%。热应激对缺血后心肌和内皮功能均有改善作用。
The aim of this study was to investigate the role of heat-shock proteins after heat-shock stress on the postischemic recovery of cardiac mechanical and endothelial function following a prolonged cardiac arrest. Isolated working rat hearts were subjected to a cardioplegic arrest for 4 hours at 4 degrees C. Three groups (n = 8 in each) were studied: (1) control, (2) sham-treated, and (3) heat-shocked rats. Postischemic recovery of cardiac output and endothelial function (as percent of preischemic control values) was 57.8% +/- 2.8% and 20.8% +/- 3.9% in group 1, 50.9% +/- 4.0% and 26.3% +/- 5.9% in group 2, and 74.0% +/- 2.4% and 51.2% +/- 8.0% in group 3, respectively. Both postischemic myocardial and endothelial function were improved by heat stress.