Neurotransmitters and neuropeptides in blood pressure regulation in the spontaneously hypertensive rat.
Neurotransmitters and neuropeptides in blood pressure regulation in the spontaneously hypertensive rat.
复制标题
神经递质和神经肽在自发性高血压大鼠血压调节中的作用。
DOI：
10.1139/y87-256
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发表时间：
1987
影响因子：
2.1
通讯作者：
B. Jarrott
中科院分区：
文献类型：
--
作者：
W. Louis;E. Conway;L. Howes;C. Maccarrone;P. Beart;B. Jarrott
神经递质在自发性高血压 (SHR) 大鼠高血压发展中所起作用的研究由于 SHR 和正常血压对照大鼠之间存在遗传差异而变得复杂，这些差异与血压差异无关。试图克服这一困难的一种方法是研究神经递质和代谢物水平随年龄变化的方式，并将这些变化与随年龄增长而发生的血压变化联系起来。 SHR 和 Wistar京都大鼠脑干和脊髓中的去甲肾上腺素 (NA) 水平随着年龄的增长而下降，而 3,4-二羟基苯乙二醇 (DHPG) 水平（去甲肾上腺素的神经元代谢物）保持恒定。当在离散的脑干 A1、A2 和 C2 区域测量 NA 和 DHPG 水平时，以及在 C1 区域检查肾上腺素、NA 和 DHPG 水平时，也会出现类似的变化。下丘脑腹内侧核和蓝斑中的神经肽 Y (NPY) 水平与年龄相关的变化也存在差异，下丘脑前核、脑干副巨细胞核和蓝斑中的 β-内啡肽水平也存在差异。这些变化可能表明随着年龄的增长，交感兴奋性 C1 区域神经元活性逐渐增加，或血管抑制 A1、A2 和 C2 区域活性逐渐减少，或两者兼而有之。然而，两种品系中儿茶酚胺和代谢物随年龄的变化相似，因此不能轻易解释 SHR 大鼠中血压随年龄增长而更快上升。
Studies of the roles played by neurotransmitters in the development of hypertension in the spontaneously hypertensive (SHR) rat are complicated by the presence of genetic differences between SHR and normotensive control rats, which are not related to differences in blood pressure. One approach that may be used in an attempt to overcome this difficulty is to study the manner in which neurotransmitter and metabolite levels change with age, and to relate these changes to alterations in blood pressure with ageing. Noradrenaline (NA) levels in the brainstem and spinal cord of SHR and Wistar Kyoto rats fell with age, while 3,4-dihydroxyphenylethyleneglycol (DHPG) levels (a neuronal metabolite of noradrenaline) remained constant. Similar changes were seen when NA and DHPG levels were measured in the discrete brainstem A1, A2, and C2 region, and when adrenaline, NA, and DHPG levels were examined in the C1 region. Differences in age-related changes of neuropeptide Y (NPY) levels were also found in the ventromedial nucleus of the hypothalamus and the locus coeruleus, and of beta-endorphin in the anterior hypothalamic nucleus, the paragigantocellular nucleus of the brainstem, and the locus coeruleus. These changes may indicate either a progressive increase in the activity of neurons in the sympathoexcitatory C1 region or a progressive reduction in the activity of vasodepressor A1, A2, and C2 regions with ageing, or both. However, changes in catecholamines and metabolites with age were similar in both strains and therefore cannot readily explain the more rapid rise in blood pressure with ageing in SHR rats.