Amplitude modulations of cortical sensory responses in pulsatile evidence accumulation.
Amplitude modulations of cortical sensory responses in pulsatile evidence accumulation.
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DOI：
10.7554/elife.60628
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发表时间：
2020-12-02
期刊：
影响因子：
7.7
通讯作者：
Tank DW
中科院分区：
文献类型：
--
作者：
Koay SA;Thiberge S;Brody CD;Tank DW
大脑如何在内部表示共同驱动决策行为的一系列感觉信息？对知觉决策的研究通常认为，感觉皮层向下游过程提供嘈杂但真实的感觉输入，这些过程积累并驱动决策。然而，即使是最早的感觉皮质中的感觉处理也可以被各种外部和内部环境系统地改变。我们记录了小鼠根据随机定时的视觉证据脉冲进行导航决策任务时，大脑后部皮质的神经元群体。即使在V1中，也只有一小部分活跃的神经元对每个脉冲有时间锁定的感觉样反应。在这里，我们关注这些“线索锁定”神经元如何表现出从感觉到认知的各种幅度调制，特别是通过选择和积累的证据。这些与任务相关的调节影响了后脑皮质中很大一部分线索锁定神经元，这表明未来的行为模式应该考虑到这种影响。
How does the brain internally represent a sequence of sensory information that jointly drives a decision-making behavior? Studies of perceptual decision-making have often assumed that sensory cortices provide noisy but otherwise veridical sensory inputs to downstream processes that accumulate and drive decisions. However, sensory processing in even the earliest sensory cortices can be systematically modified by various external and internal contexts. We recorded from neuronal populations across posterior cortex as mice performed a navigational decision-making task based on accumulating randomly timed pulses of visual evidence. Even in V1, only a small fraction of active neurons had sensory-like responses time-locked to each pulse. Here, we focus on how these ‘cue-locked’ neurons exhibited a variety of amplitude modulations from sensory to cognitive, notably by choice and accumulated evidence. These task-related modulations affected a large fraction of cue-locked neurons across posterior cortex, suggesting that future models of behavior should account for such influences.