EFFECTS OF METHADONE ON FREE FEEDING IN SATIATED RATS
EFFECTS OF METHADONE ON FREE FEEDING IN SATIATED RATS
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DOI：
10.1016/0091-3057(92)90477-w
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发表时间：
1992-12-01
影响因子：
3.6
通讯作者：
LEVINE, AS
中科院分区：
文献类型：
--
作者：
RUDSKI, JM;SCHAAL, DW;LEVINE, AS
已知各种阿片类药物和阿片类药物会增加短期食物摄入量。在本研究中，我们评估了美沙酮对饱食大鼠自由进食的影响。我们评估了美沙酮（0，1.5，3.0，5.0和10.0 mg/kg）对食物摄入量的影响，注射后1，2，4和6小时，连续3天。美沙酮给药后2小时，食物摄入量与剂量呈负相关，但6小时后，剂量和喂养之间的直接关系。食物摄入量随着重复美沙酮给药而增加。在实验2中，注射美沙酮（5.0 mg/kg），并在0、1、2或3 h后提供食物。美沙酮给药后第三和第四小时出现最大摄食量。如在实验1中，食物摄入量随着重复美沙酮给药而增加。重复美沙酮给药后食物摄入量增加可能是由于对美沙酮影响的耐受性的发展，美沙酮可能会干扰进食，如镇静。在实验3中，每天或每五天给予美沙酮，假设间隔注射将延迟耐受性发展。重复每日美沙酮给药与会议早期食物摄入量增加有关，而间隔美沙酮给药后食物摄入量增加发生在会议后期。这些数据表明，美沙酮增加了饱足大鼠的短期进食。这与操作性研究中所报告的食物强化行为减少形成对比。这种对比可能是由于美沙酮的镇静或其他致残作用。
A variety of opioids and opiates are known to increase short-term food intake. In the present study, we evaluated the effects of methadone on free feeding in satiated rats. We assessed the effect of methadone (0, 1.5, 3.0, 5.0, and 10.0 mg/kg) on food intake 1, 2, 4, and 6 h after injection for 3 consecutive days. Two hours after methadone administration, food intake was inversely related to dose, but after 6 h a direct relationship between dose and feeding was obtained. Food intake increased with repeated methadone administration. In Experiment 2, methadone (5.0 mg/kg) was injected and food was made available 0, 1, 2, or 3 h later. Maximal food intake occurred in the third and fourth hours following methadone administration. As in Experiment 1, food intake increased with repeated methadone administration. Increases in food intake following repeated methadone administration may have been due to the development of tolerance to effects of methadone that may interfere with feeding, such as sedation. In Experiment 3, methadone was administered daily or every fifth day, assuming that spacing injections would retard tolerance development. Repeated daily methadone administration was associated with increased food intake earlier in the session, whereas increases in food intake following spaced methadone administration occurred later in the session. These data indicate that methadone increases short-term feeding in satiated rats. This is in contrast to the reported decrease in food-reinforced behavior noted in operant studies. This contrast may be due to sedating or other disabling effects of methadone.