Research progress regarding the effect and mechanism of dietary phenolic acids for improving nonalcoholic fatty liver disease via gut microbiota.
Research progress regarding the effect and mechanism of dietary phenolic acids for improving nonalcoholic fatty liver disease via gut microbiota.
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DOI：
10.1111/1541-4337.13106
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发表时间：
2023-01
影响因子：
14.8
通讯作者：
Lin Ji;Huan Deng;Huimin Xue;Jiting Wang;Kexin Hong;Yunxiao Gao;Xiping Kang;Guanghe Fan;Weidong Huang;J. Zhan;Yilin You
中科院分区：
文献类型：
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作者：
Lin Ji;Huan Deng;Huimin Xue;Jiting Wang;Kexin Hong;Yunxiao Gao;Xiping Kang;Guanghe Fan;Weidong Huang;J. Zhan;Yilin You
酚酸（phenolicacids，PAs）是一类广泛存在于食品中的生物活性小分子，主要以植物次生代谢产物的形式存在，具有抗氧化和其他保健功能。非酒精性脂肪性肝病（NAFLD）的全球流行正在成为一个严重的公共卫生问题。现有研究表明，肠道微生物群（GM）失调与NAFLD的发生和发展密切相关。近年来，PA类化合物与GM、NAFLD关系的研究取得了一定进展。PAs可以调节GM的组成和功能，促进人类健康，而GM可以增加PAs的膳食来源，提高其生物利用度。本文讨论了多胺、转基因及其相互关系，介绍了几种典型的膳食多胺来源，并考察了转基因介导的多胺吸收和代谢。本文还综述了PAs通过GM及其代谢产物改善和调节NAFLD的作用及其机制。这有助于更好地评估PAs通过转基因调控对NAFLD的潜在预防作用，并扩大PAs和富含PAs的食品资源的利用。
Phenolic acids (PAs), a class of small bioactive molecules widely distributed in food and mainly found as secondary plant metabolites, present significant advantages such as antioxidant activity and other health benefits. The global epidemic of nonalcoholic fatty liver disease (NAFLD) is becoming a serious public health problem. Existing studies showed that gut microbiota (GM) dysbiosis is highly associated with the occurrence and development of NAFLD. In recent years, progress has been made in the study of the relationship among PA compounds, GM, and NAFLD. PAs can regulate the composition and functions of the GM to promote human health, while GM can increase the dietary sources of PAs and improve its bioavailability. This paper discussed PAs, GM, and their interrelationship while introducing several representative dietary PA sources and examining the absorption and metabolism of PAs mediated by GM. It also summarizes the effect and mechanisms of PAs in improving and regulating NAFLD via GM and their metabolites. This helps to better evaluate the potential preventive effect of PAs on NAFLD via the regulation of GM and expands the utilization of PAs and PA-rich food resources.