Function of epithelial stem cell in the repair of alveolar injury.
Function of epithelial stem cell in the repair of alveolar injury.
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DOI：
10.1186/s13287-022-02847-7
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发表时间：
2022-04-27
影响因子：
7.5
通讯作者：
Liu, Yuru
中科院分区：
文献类型：
--
作者：
Chan, Manwai;Liu, Yuru
肺泡是肺内血气交换的功能单位，因此经常暴露在外界环境中，经常遇到病原体、颗粒等有害物质。例如，肺泡上皮是导致COVID-19肺部疾病的SARS-CoV-2病毒的主要目标之一。因此，了解维持肺泡上皮屏障完整性的细胞和分子机制至关重要。肺泡上皮包括两种细胞类型：肺泡I型细胞（AT1）和肺泡II型细胞（AT2）。AT2s已被证明可以作为组织干细胞修复受损的肺泡上皮。最近的研究表明，at1和近端气道上皮细胞亚群也可以通过其固有的可塑性参与肺泡修复过程。本文讨论了AT2、AT1和一些近端细胞在损伤反应中修复行为的潜在机制，以及异常修复如何导致一些病理状况。
Alveoli are the functional units of blood-gas exchange in the lung and thus are constantly exposed to outside environments and frequently encounter pathogens, particles and other harmful substances. For example, the alveolar epithelium is one of the primary targets of the SARS-CoV-2 virus that causes COVID-19 lung disease. Therefore, it is essential to understand the cellular and molecular mechanisms by which the integrity of alveoli epithelial barrier is maintained. Alveolar epithelium comprises two cell types: alveolar type I cells (AT1) and alveolar type II cells (AT2). AT2s have been shown to function as tissue stem cells that repair the injured alveoli epithelium. Recent studies indicate that AT1s and subgroups of proximal airway epithelial cells can also participate alveolar repair process through their intrinsic plasticity. This review discussed the potential mechanisms that drive the reparative behaviors of AT2, AT1 and some proximal cells in responses to injury and how an abnormal repair contributes to some pathological conditions.
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影响因子：
64.5
作者：
Hou, Yixuan J.;Okuda, Kenichi;Baric, Ralph S.
通讯作者：
Baric, Ralph S.
影响因子：
23.9
作者：
Dost AFM;Moye AL;Vedaie M;Tran LM;Fung E;Heinze D;Villacorta-Martin C;Huang J;Hekman R;Kwan JH;Blum BC;Louie SM;Rowbotham SP;Sainz de Aja J;Piper ME;Bhetariya PJ;Bronson RT;Emili A;Mostoslavsky G;Fishbein GA;Wallace WD;Krysan K;Dubinett SM;Yanagawa J;Kotton DN;Kim CF
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影响因子：
16.6
作者：
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通讯作者：
Epstein, Jonathan A.
DOI：
10.1242/dev.163014
发表时间：
2018-05-11
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Chung MI;Bujnis M;Barkauskas CE;Kobayashi Y;Hogan BLM
通讯作者：
Hogan BLM
影响因子：
8.8
作者：
Finn, Johanna;Sottoriva, Kilian;Liu, Yuru
通讯作者：
Liu, Yuru