Herpes simplex virus type-1: a model for genome transactions.
Herpes simplex virus type-1: a model for genome transactions.
复制标题
1 型单纯疱疹病毒：基因组交易模型。
DOI：
10.1016/s0079-6603(03)75005-3
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Villani,Giuseppe
中科院分区：
文献类型：
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作者：
Boehmer,PaulE;Villani,Giuseppe
在许多方面，HSV-1是原型疱疹病毒。然而，HSV-1也是一个很好的模型系统来研究基因组的交易，包括DNA复制，同源重组，和DNA复制酶与DNA损伤的相互作用。与真核细胞染色体一样，HSV-1基因组包含多个复制起点。HSV-1基因组的复制是由几种病毒编码蛋白的协同作用介导的，这些蛋白被认为组装成多蛋白复合物。一些宿主编码的因子也与病毒DNA复制有关。此外，已知HSV-1基因组的复制与同源重组密切相关，同源重组与许多细胞生物一样，可能在重组修复中起作用。最后，最近的数据揭示了HSV-1复制蛋白，特别是其DNA聚合酶和DNA解旋酶与受损DNA的相互作用。
In many respects, HSV-1 is the prototypic herpes virus. However, HSV-1 also serves as an excellent model system to study genome transactions, including DNA replication, homologous recombination, and the interaction of DNA replication enzymes with DNA damage. Like eukaryotic chromosomes, the HSV-1 genome contains multiple origins of replication. Replication of the HSV-1 genome is mediated by the concerted action of several virus-encoded proteins that are thought to assemble into a multiprotein complex. Several host-encoded factors have also been implicated in viral DNA replication. Furthermore, replication of the HSV-1 genome is known to be closely associated with homologous recombination that, like in many cellular organisms, may function in recombinational repair. Finally, recent data have shed some light on the interaction of essential HSV-1 replication proteins, specifically its DNA polymerase and DNA helicases, with damaged DNA.