An analysis of image texture, tumor location, and MGMT promoter methylation in glioblastoma using magnetic resonance imaging
An analysis of image texture, tumor location, and MGMT promoter methylation in glioblastoma using magnetic resonance imaging
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DOI：
10.1016/j.neuroimage.2009.09.049
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发表时间：
2010-01-15
期刊：
影响因子：
5.7
通讯作者：
Mitchell, J. Ross
中科院分区：
文献类型：
--
作者：
Drabycz, Sylvia;Roldan, Gloria;Mitchell, J. Ross
在胶质母细胞瘤（GBM）中，DNA修复基因o -6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）的启动子甲基化与化疗的获益相关。据报道，MGMT启动子甲基化与磁共振（MR）视觉评估成像特征之间的相关性表明，对MGMT甲基化状态的无创检测可能是可能的。我们的研究评估了是否可以使用磁共振成像预测GBM中的MGMT甲基化状态。我们对新诊断的GBM患者的MR图像进行了回顾性分析。采用两种方法评价肿瘤的质地。首先，我们通过专家共识来分析纹理，描述肿瘤边界、囊肿的存在或不存在、增强模式和肿瘤信号在t2加权图像中的表现。然后，应用基于s变换的空频纹理分析。使用自动图像配准和分割技术确定脑内肿瘤的位置。分析了它们与MGMT甲基化的关系。我们证实，视觉评估的环增强与未甲基化的MGMT启动子状态显著相关（P = 0.006）。空间频率分析评估的t2加权图像纹理特征在甲基化和非甲基化病例之间存在显著差异(P
In glioblastoma (GBM), promoter methylation of the DNA repair gene O-6-methylguanine-DNA methyltransferase (MGMT) is associated with benefit from chemotherapy. Correlations between MGMT promoter methylation and visually assessed imaging features on magnetic resonance (MR) have been reported suggesting that noninvasive detection of MGMT methylation status might be possible. Our study assessed whether MGMT methylation status in GBM could be predicted using MR imaging. We conducted a retrospective analysis of MR images in patients with newly diagnosed GBM. Tumor texture was assessed by two methods. First, we analyzed texture by expert consensus describing the tumor borders, presence or absence of cysts, pattern of enhancement, and appearance of tumor signal in T2-weighted images. Then, we applied space-frequency texture analysis based on the S-transform. Tumor location within the brain was determined using automatized image registration and segmentation techniques. Their association with MGMT methylation was analyzed. We confirmed that ring enhancement assessed visually is significantly associated with unmethylated MGMT promoter status (P = 0.006). Texture features on T2-weighted images assessed by the space-frequency analysis were significantly different between methylated and unmethylated cases (P