Genetics of salt-sensitive hypertension.
Genetics of salt-sensitive hypertension.
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DOI：
10.1007/s11906-010-0167-6
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发表时间：
2011-02
影响因子：
5.6
通讯作者：
Jose, Pedro A.
中科院分区：
文献类型：
--
作者：
Sanada, Hironobu;Jones, John E.;Jose, Pedro A.
关键词：
由于对血压盐敏感性的定义缺乏普遍共识，因此难以评估血压盐敏感性。不管盐敏感性定义的变化，盐摄入量增加，独立于实际血压水平，也是心血管发病率和死亡率以及肾脏疾病的风险因素。适度减少盐的摄入量会立即降低血压，并产生长期有益的后果。然而，有些人认为，饮食中的钠限制可能并不对每个人都有益。因此，有必要区分盐敏感和耐盐个体，但很难通过表型研究做到这一点。因此，有必要确定参与盐敏感性的基因。本文综述了与盐敏感性相关的基因，重点是与人类盐敏感性相关的变异，而不是由于单基因原因。特别强调与盐敏感性相关的基因变异，其蛋白质产物干扰转基因小鼠的细胞功能并增加血压。
The assessment of salt sensitivity of blood pressure is difficult because of the lack of universal consensus on definition. Regardless of the variability in the definition of salt sensitivity, increased salt intake, independent of the actual level of blood pressure, is also a risk factor for cardiovascular morbidity and mortality and kidney disease. A modest reduction in salt intake results in an immediate decrease in blood pressure, with long-term beneficial consequences. However, some have suggested that dietary sodium restriction may not be beneficial to everyone. Thus, there is a need to distinguish salt-sensitive from salt-resistant individuals, but it has been difficult to do so with phenotypic studies. Therefore, there is a need to determine the genes that are involved in salt sensitivity. This review focuses on genes associated with salt sensitivity, with emphasis on the variants associated with salt sensitivity in humans that are not due to monogenic causes. Special emphasis is given to gene variants associated with salt sensitivity whose protein products interfere with cell function and increase blood pressure in transgenic mice.
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