Plasma concentration of urotensin II is raised in hypertension
Plasma concentration of urotensin II is raised in hypertension
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DOI：
10.1097/01.hjh.0000125452.28861.f1
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发表时间：
2004-07-01
影响因子：
4.9
通讯作者：
Wong, LYF
中科院分区：
文献类型：
--
作者：
Cheung, BMY;Leung, R;Wong, LYF
目的尿紧张素II是已知最有效的血管收缩剂。其在高血压中的作用尚未被调查。在这里，我们研究了高血压和正常血压的人的血浆水平。设计横断面病例对照研究。设置大学教学医院高血压门诊和研究门诊。参与者：从普通人群中招募62名高血压门诊患者（52%为男性，年龄57 +/- 13岁）和62名正常对照组（45%为男性，年龄54 +/- 13岁）。主要结果测量血浆尿紧张素II水平通过放射免疫测定，收缩压和舒张压。结果正常对照组血浆尿紧张素II为8.8 +/- 0.9 pmol/l，高血压组为13.6 +/- 1.4 pmol/l （P = 0.005）。在多元回归分析中，收缩压与血浆尿紧张素II （P = 0.31, P < 0.001）和年龄（P = 0.28, P = 0.001）相关，分别占收缩压方差的10%和8%。与性别、肾功能、糖尿病无显著相关性。结论与正常对照组相比，高血压患者血浆尿紧张素II升高，并与收缩压直接相关。我们的发现提高了尿紧张素II可能在高血压及其并发症中具有病因学作用的可能性。
Objectives Urotensin II is the most potent vasoconstrictor known. Its role in hypertension has not been investigated. Here, we studied the plasma levels in hypertensive and normotensive human subjects.Design A cross-sectional case-control study.Setting Hypertension clinic and research clinic of a university teaching hospital.Participants Sixty-two hypertensive outpatient subjects (52% male, aged 57 +/- 13 years) and 62 normotensive controls (45% male, aged 54 +/- 13 years) recruited from the general population.Main outcome measures Plasma urotensin II levels measured by radioimmunoassay, systolic and diastolic blood pressure.Results Plasma urotensin II was 8.8 +/- 0.9 pmol/l in normotensive controls and 13.6 +/- 1.4 pmol/l in hypertensive subjects (P = 0.005). In multiple regression analysis, systolic blood pressure was related to plasma urotensin II (P = 0.31, P < 0.001) and age (P = 0.28, P = 0.001), accounting for 10 and 8%, respectively, of the variance in systolic blood pressure. There was no significant correlation with gender, renal function or diabetes.Conclusions Plasma urotensin II was raised in hypertensive patients compared to normotensive controls, and was directly related to systolic blood pressure. Our findings raise the possibility that urotensin II may have an aetiological role in hypertension and its complications.