Monochromatic Propagation-Based Phase-Contrast Microscale Computed-Tomography System with a Rotating-Anode Source
Monochromatic Propagation-Based Phase-Contrast Microscale Computed-Tomography System with a Rotating-Anode Source
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DOI：
10.1103/physrevapplied.11.034004
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发表时间：
2019-03-04
影响因子：
4.6
通讯作者：
Endrizzi, M.
中科院分区：
文献类型：
--
作者：
Brombal, L.;Kallon, G.;Endrizzi, M.
我们提出了一种基于单色传播的X射线相衬成像的实验装置，该装置基于传统的铜阳极源，能够在8 keV下获得高达10（8）光子/s的积分通量。在我们的研究中，该系统的特点是在空间相干性，分辨率，对比灵敏度和稳定性。它的定量证明了通过比较理论预测与实验数据在平面和计算机断层扫描几何形状的简单线幻影。两个生物样品的医学兴趣的应用程序显示了潜在的毫米级的生物成像的空间分辨率的顺序为10 μ m和对比度分辨率低于1%。所有扫描都在实验室兼容的曝光时间内进行，从10分钟到几个小时，并讨论了扫描时间和图像质量之间的权衡。
We present an experimental setup for monochromatic propagation-based x-ray phase-contrast imaging based on a conventional rotating-copper-anode source, capable of an integrated flux up to 10(8) photons/s at 8 keV. In our study, the system is characterized in terms of spatial coherence, resolution, contrast sensitivity, and stability. Its quantitativeness is demonstrated by comparing theoretical predictions with experimental data on simple wire phantoms both in planar and computerized-tomography-scan geometries. Application to two biological samples of medical interest shows the potential for bioimaging on the millimeter scale with spatial resolution of the order of 10 mu m and contrast resolution below 1%. All the scans are performed within laboratory-compatible exposure times, from 10 min to a few hours, and trade-offs between scan time and image quality are discussed.